{"id":"W4388693128","doi":"10.1101/2023.11.11.566693","title":"The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut Universitaire de Gériatrie de Montréal; McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; National Institute of Neurological Disorders and Stroke; Verily Life Sciences; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Parkinson Canada; Compute Canada; McGill University; Celgene; Sanofi; GlaxoSmithKline; Parkinson's Foundation; Pfizer; Bristol-Myers Squibb; Brookdale Foundation; Michael J. Fox Foundation for Parkinson's Research; National Institutes of Health; Canada First Research Excellence Fund; U.S. Department of Health and Human Services","keywords":"Alpha-synuclein; Cathepsin B; Autophagy; Biology; Cell biology; Lysosome; Glucocerebrosidase; Cathepsin D; Dopaminergic; Synucleinopathies; Parkinson's disease; Biochemistry; Neuroscience; Dopamine; Gene; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714064,0.0002219882,0.0002019432,0.0002550324,0.0001232978,0.0002880674,0.0001136238,0.0002427232,0.0009691913],"category_scores_gemma":[0.0001229354,0.0001704209,0.0002391901,0.0001572469,0.0002304639,0.00007987308,0.0001584664,0.0003999177,0.0001331607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436439,"about_ca_system_score_gemma":0.0001701078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008273575,"about_ca_topic_score_gemma":0.001305804,"domain_scores_codex":[0.9998525,0.00002623553,0.00002125777,0.00003690549,0.00003918978,0.00002383339],"domain_scores_gemma":[0.9998527,0.00003067414,0.00004578823,0.00001560854,0.00000997469,0.00004520592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001193706,0.00002945403,0.0005930475,0.00001518442,0.00001345354,0.00007005964,0.000009872255,0.00004575362,0.9987004,0.00003536331,0.00001590898,0.0003520331],"study_design_scores_gemma":[0.00007462718,0.0004317206,0.0402731,0.0000118612,0.00005795826,0.0008396328,0.0000561288,0.001927705,0.9550509,0.00009061792,0.001178617,0.000007107722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987211,0.0003476761,0.0004427283,0.00003855487,0.000007393503,0.000005500865,0.0001969242,0.00001378109,0.0002263466],"genre_scores_gemma":[0.9985166,0.0001926918,0.0004154248,0.00001872357,0.000002424779,0.00000975711,0.0002397764,0.000005768207,0.0005988402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009691913,"threshold_uncertainty_score":0.003242314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531806189436089,"score_gpt":0.2232205641450695,"score_spread":0.2079025022507086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}