{"id":"W4388695093","doi":"10.1001/jamacardio.2023.4147","title":"Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy","year":2023,"lang":"en","type":"article","venue":"JAMA Cardiology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Ejection fraction; Medicine; Cardiology; Placebo; Internal medicine; Cardiomyopathy; Cardiac function curve; Heart failure; Randomized controlled trial; Stroke volume; Transthyretin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004957801,0.0003047062,0.0007235399,0.0001972892,0.00004304105,0.000008395235,0.000155447,0.0003409228,0.000005162714],"category_scores_gemma":[0.0001383456,0.0002393358,0.0003449558,0.0003377881,0.0001273452,0.000006203633,0.00006248442,0.0001513638,0.00004576598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005399123,"about_ca_system_score_gemma":0.0000358912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003799626,"about_ca_topic_score_gemma":0.000007607521,"domain_scores_codex":[0.9978968,0.000634743,0.0002804155,0.0005664205,0.0002125309,0.0004091046],"domain_scores_gemma":[0.9990718,0.000149825,0.0001052117,0.0005304196,0.00007205147,0.00007068316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002203787,0.00004557706,0.9792708,0.00004731453,0.0004756047,0.00001383949,0.00003354267,0.00136365,0.005893571,0.00001818555,0.001819525,0.008814657],"study_design_scores_gemma":[0.003923799,0.006333898,0.9569269,0.00002623614,0.0001673715,0.000001792382,0.00003511824,0.000003247115,0.02693368,0.000005012663,0.005396538,0.0002463473],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971563,0.0002686933,0.00004109053,0.00008915844,0.0004141302,0.0006362434,0.0001511084,0.00004158686,0.001201699],"genre_scores_gemma":[0.9983493,0.0002405483,0.00001213188,0.00009196909,0.0001854223,0.0002846313,0.0007202893,0.00004779916,0.00006788252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02234379,"threshold_uncertainty_score":0.9759831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003655700128831446,"score_gpt":0.2193583848077447,"score_spread":0.2157026846789132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}