{"id":"W4388699221","doi":"10.1101/2023.11.14.567123","title":"Development of LRRK2 designed ankyrin-repeat proteins","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Federation of Pharmaceutical Industries and Associations; McGill University; Genentech; Bayer; Pfizer; Genome Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Ankyrin repeat; Protein kinase domain; Leucine-rich repeat; Cell biology; Ankyrin; Kinase; Phosphorylation; Biology; Chemistry; Computational biology; Biochemistry; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125144,0.000453258,0.0002135458,0.0001416291,0.0001101036,0.0002328875,0.0002848806,0.0003116555,0.000780521],"category_scores_gemma":[0.0001485815,0.0001590059,0.000187087,0.0001116356,0.0001174513,0.0001884688,0.0002643213,0.0003620274,0.0004386705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996075,"about_ca_system_score_gemma":0.000147593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002124984,"about_ca_topic_score_gemma":0.000364569,"domain_scores_codex":[0.9998562,0.00002760018,0.00001457559,0.00003560238,0.00004175305,0.00002432024],"domain_scores_gemma":[0.9999194,0.000006907514,0.00002554151,0.000007006408,0.0000181563,0.00002299307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002168488,0.00003654417,0.00008237667,0.00004028421,0.00000775761,0.00008525973,0.000008791647,0.0003611483,0.9968844,0.0002513102,0.0001112747,0.002109204],"study_design_scores_gemma":[0.00001323027,0.0002045282,0.0004354978,0.000003984917,0.0000101344,0.0001994947,0.000007939841,0.001790505,0.992588,0.00003862869,0.004702167,0.000005840197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450724,0.002242961,0.04620708,0.0002757446,0.0001119385,0.0002819557,0.0003609126,0.0003217408,0.005125204],"genre_scores_gemma":[0.9475384,0.001390983,0.04439058,0.0001442664,0.00001328372,0.0001696526,0.0006368652,0.00006272133,0.005653239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000780521,"threshold_uncertainty_score":0.002611101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03375268528749606,"score_gpt":0.2530803614958594,"score_spread":0.2193276762083634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}