{"id":"W4388704104","doi":"10.3389/fncel.2023.1272899","title":"Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr175 tau","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Robarts Research Institute","keywords":"Downregulation and upregulation; Traumatic brain injury; Neuroscience; Phosphorylation; LRRK2; Medicine; Cell biology; Psychology; Chemistry; Biology; Internal medicine; Parkinson's disease; Psychiatry; Gene; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841519,0.0004480708,0.0005196926,0.0002425383,0.0002258634,0.0004380333,0.0002652978,0.0003724832,0.001614447],"category_scores_gemma":[0.000201385,0.0001853289,0.0004786444,0.0002428035,0.000391905,0.0002681211,0.0001989223,0.0009230698,0.0006508509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003700487,"about_ca_system_score_gemma":0.0002818545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007446,"about_ca_topic_score_gemma":0.001128126,"domain_scores_codex":[0.9996527,0.00004062081,0.00004783084,0.00006124067,0.00009811994,0.00009954866],"domain_scores_gemma":[0.9997981,0.00002677634,0.0000672824,0.00002880429,0.00002513188,0.00005382396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836899,0.00005559736,0.0001283648,0.00004871129,0.000009153103,0.0001055681,0.00001920252,0.00003878136,0.9989954,0.00004277605,0.00004784207,0.0003250042],"study_design_scores_gemma":[0.00003519292,0.0008721898,0.008813368,0.00001038279,0.00003339901,0.0009529373,0.0001142948,0.0008329687,0.9863439,0.00005407738,0.001926837,0.00001055088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963768,0.001017657,0.0007213452,0.0001444273,0.00005419707,0.00002737904,0.0004121254,0.00006035036,0.001185714],"genre_scores_gemma":[0.9937621,0.0006868567,0.00125999,0.00008731322,0.000020943,0.00008385681,0.001264824,0.00001753595,0.00281653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001614447,"threshold_uncertainty_score":0.005400896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03055315478377926,"score_gpt":0.3075942207535404,"score_spread":0.2770410659697611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}