{"id":"W4388704104","doi":"10.3389/fncel.2023.1272899","title":"Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr175 tau","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Robarts Research Institute","keywords":"Downregulation and upregulation; Traumatic brain injury; Neuroscience; Phosphorylation; LRRK2; Medicine; Cell biology; Psychology; Chemistry; Biology; Internal medicine; Parkinson's disease; Psychiatry; Gene; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000475002,0.0001684106,0.0003439976,0.0003778008,0.0001157644,0.00002814947,0.0002111478,0.00006117373,0.00001285213],"category_scores_gemma":[0.0002509969,0.0001314485,0.0001653346,0.001112009,0.0002182388,0.0002220544,0.00007720022,0.0001516703,0.00001930136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007555058,"about_ca_system_score_gemma":0.00014714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000349326,"about_ca_topic_score_gemma":0.000002247065,"domain_scores_codex":[0.9978634,0.000104999,0.0003274809,0.0004672319,0.0007545102,0.0004823795],"domain_scores_gemma":[0.9992056,0.00006963259,0.00009172074,0.0003864902,0.00003114075,0.0002154534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006930064,0.0008417557,0.3467489,0.000385926,0.0004639386,0.001643359,0.001426243,0.0002826278,0.6105332,0.00008463423,0.003927617,0.03296882],"study_design_scores_gemma":[0.002847225,0.0006655965,0.3605548,0.0003923343,0.0002578808,0.000006176598,0.0005459806,0.05311376,0.5787501,0.002076131,0.0003647654,0.0004252444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957544,0.0009537743,0.0008373467,0.0005051251,0.001046476,0.0005728657,0.00002410812,0.00009318686,0.0002127715],"genre_scores_gemma":[0.9983476,0.0001445696,0.0006212604,0.0001306843,0.000022408,0.00003092756,0.00002168751,0.00002492513,0.000655942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05283114,"threshold_uncertainty_score":0.5360315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03055315478377926,"score_gpt":0.3075942207535404,"score_spread":0.2770410659697611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}