{"id":"W4388712457","doi":"10.32604/or.2023.030401","title":"Biological, pathological, and multifaceted therapeutic functions of exosomes to target cancer","year":2023,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Durham College","funders":"Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education","keywords":"Microvesicles; Exosome; Intracellular; Cell biology; Function (biology); microRNA; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003039503,0.0002387681,0.0005575037,0.0001144737,0.0002634159,0.00003391212,0.0004027885,0.0007619532,0.00007351513],"category_scores_gemma":[0.001153,0.0001818308,0.0001692405,0.0005182418,0.001712889,0.000007970638,0.0008168713,0.0008546048,0.00002175152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003212693,"about_ca_system_score_gemma":0.0003204474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003027727,"about_ca_topic_score_gemma":0.00005373476,"domain_scores_codex":[0.9960318,0.001326244,0.0007432763,0.0009434227,0.0002921437,0.000663122],"domain_scores_gemma":[0.996855,0.001683235,0.000148278,0.0004941938,0.000373661,0.0004456593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002854554,0.001088064,0.4756633,0.0000937997,0.0007191665,0.00004567717,0.0002045105,0.0001090122,0.1598597,0.0001223661,0.00179217,0.3574477],"study_design_scores_gemma":[0.002973445,0.006879481,0.7330332,0.0001085027,0.0001731007,0.00001636257,0.0006031456,0.0004058536,0.008858944,0.002387059,0.2439901,0.0005707915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773803,0.01530847,0.00009357814,0.005862336,0.0003852551,0.0005967766,0.0001371996,0.00005772595,0.000178298],"genre_scores_gemma":[0.9375533,0.05773491,0.0009578191,0.001537004,0.0004589538,0.0002921778,0.00003920928,0.00003602838,0.00139062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3568769,"threshold_uncertainty_score":0.7414843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2954338355755112,"score_gpt":0.527769437303063,"score_spread":0.2323356017275518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}