{"id":"W4388721885","doi":"10.1038/s41598-023-47172-y","title":"Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dysbiosis; Lactobacillus; Microbiology; Chemokine; Inflammation; Short-chain fatty acid; Vagina; Immunology; Chemistry; Biology; Bacteria; Biochemistry; Gut flora; Butyrate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331541,0.0002493062,0.0003224089,0.0002082197,0.0001268697,0.0003456914,0.0002115932,0.0002648275,0.001453131],"category_scores_gemma":[0.0001369897,0.0001120728,0.0002260629,0.0001468065,0.0001075121,0.0001949737,0.0002457623,0.0006074663,0.0001364153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221827,"about_ca_system_score_gemma":0.0002201435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005867509,"about_ca_topic_score_gemma":0.001248336,"domain_scores_codex":[0.9998441,0.00004781134,0.00001251117,0.00001668347,0.00003622583,0.00004270018],"domain_scores_gemma":[0.9999442,0.000007311983,0.00001364674,0.0000054703,0.000009810855,0.00001959367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001287924,0.0004083321,0.0005076132,0.0002302856,0.00002258561,0.00008395543,0.00003356131,0.00009416821,0.9834576,0.0000738707,0.000124001,0.01367606],"study_design_scores_gemma":[0.0001622323,0.0104169,0.02542301,0.0001184307,0.0001177087,0.0005495962,0.0002477924,0.001208454,0.9484521,0.0001823399,0.01310665,0.0000148562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853246,0.01202071,0.0007717473,0.0001856372,0.00006348435,0.00004128564,0.0002162922,0.00004607072,0.001330269],"genre_scores_gemma":[0.9915251,0.004365553,0.00149186,0.0001300296,0.00002353253,0.00003700767,0.0003467493,0.000009988875,0.002070097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453131,"threshold_uncertainty_score":0.004861236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292387768522522,"score_gpt":0.2777781229645008,"score_spread":0.2648542452792756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}