{"id":"W4388722600","doi":"10.1021/acschemneuro.3c00576","title":"Small Molecules <i>N</i>-Phenylbenzofuran-2-carboxamide and <i>N</i>-Phenylbenzo[<i>b</i>]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Fibrillogenesis; Cytotoxicity; Chemistry; Neurotoxicity; Viability assay; Hippocampal formation; Biophysics; In vitro; Trypan blue; Carboxamide; Biochemistry; Toxicity; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008125552,0.0003863053,0.0002219894,0.0001452814,0.0001142012,0.0001513868,0.0002349326,0.0002494793,0.001050224],"category_scores_gemma":[0.00008205176,0.00009885233,0.0002274292,0.00008777494,0.000138055,0.0002047795,0.00007962493,0.0003571905,0.0003137053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235328,"about_ca_system_score_gemma":0.0001275025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003311495,"about_ca_topic_score_gemma":0.0006519809,"domain_scores_codex":[0.9999413,0.00000981429,0.000003585194,0.0000119108,0.00001749989,0.00001577237],"domain_scores_gemma":[0.9999516,0.000007757353,0.00001626356,0.000003880176,0.00001026461,0.0000103088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008469816,0.00003645616,0.00005119449,0.00006394651,0.00000639252,0.00004817062,0.000005285362,0.00008040034,0.9974517,0.00007349964,0.00006741355,0.00203081],"study_design_scores_gemma":[0.0000271876,0.001075863,0.001604581,0.000006614846,0.00001777096,0.000274479,0.00000970302,0.000379609,0.9941268,0.00002657311,0.002444222,0.000006628499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762438,0.008063998,0.007759639,0.0001720277,0.00007527398,0.0001044089,0.0003073453,0.0001764793,0.007097029],"genre_scores_gemma":[0.9875051,0.004145493,0.005414309,0.0001345053,0.00004226647,0.00008709017,0.0003427475,0.00001823348,0.002310255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050224,"threshold_uncertainty_score":0.003513396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389414597663494,"score_gpt":0.2814786793501998,"score_spread":0.2425372195838504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}