{"id":"W4388724871","doi":"10.22541/au.170011992.20997426/v1","title":"Inhibition of HCN1 currents by norquetiapine, an active metabolite of the atypical anti-psychotic drug quetiapine","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Quetiapine; Quetiapine Fumarate; Pharmacology; Schizophrenia (object-oriented programming); Chemistry; Metabolite; Phencyclidine; Antipsychotic; Atypical antipsychotic; Neuroscience; Medicine; Psychology; Biochemistry; Psychiatry; NMDA receptor; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008874542,0.0001883765,0.0001546088,0.0001096674,0.0000942544,0.0001983621,0.000273878,0.0001712427,0.0008214093],"category_scores_gemma":[0.0001880156,0.00006718149,0.0001625288,0.00007172437,0.0001600189,0.0001273611,0.00007867116,0.0003414138,0.0001564481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843476,"about_ca_system_score_gemma":0.0002451862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002752398,"about_ca_topic_score_gemma":0.004748883,"domain_scores_codex":[0.999926,0.000009572634,0.000009004259,0.00001482582,0.0000235499,0.00001696155],"domain_scores_gemma":[0.9999157,0.00002845259,0.0000196185,0.000006646833,0.00001561107,0.00001385219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155157,0.00001092164,0.000105516,0.00004967022,0.000004343216,0.00003536957,0.00001453201,0.00003287406,0.9982886,0.00009573848,0.0000518083,0.00119511],"study_design_scores_gemma":[0.00004655109,0.000370575,0.005535291,0.00001102774,0.00002174359,0.0003014953,0.00002672241,0.001211589,0.9886366,0.00003673042,0.003795723,0.000005992041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897714,0.003227509,0.002368731,0.0001547211,0.0000527425,0.00005349823,0.0004175936,0.00009346652,0.003860228],"genre_scores_gemma":[0.9936539,0.002056453,0.002330011,0.00007195165,0.00001605455,0.00003239066,0.0003314248,0.00001353224,0.001494236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002752398,"threshold_uncertainty_score":0.005472779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731339841145227,"score_gpt":0.2791127146669747,"score_spread":0.2617993162555224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}