{"id":"W4388725626","doi":"10.1186/s13024-023-00673-w","title":"Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons","year":2023,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dementias Platform UK; National Institute of Neurological Disorders and Stroke; Stem Cell Network; Medical Research Council; Parkinson's UK; National Institutes of Health","keywords":"Lysosome; Proteostasis; Biology; Cell biology; Batten disease; Proteomics; Neuronal ceroid lipofuscinosis; Neurodegeneration; Neuroscience; Biochemistry; Gene; Enzyme; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004331,0.000298423,0.0002477376,0.0003858785,0.0001423546,0.0003156358,0.0001715709,0.0002202646,0.0003766433],"category_scores_gemma":[0.00009104699,0.0001042797,0.0002813428,0.0002060669,0.0001549825,0.0001595468,0.0002289762,0.0003264971,0.0001900036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003083651,"about_ca_system_score_gemma":0.0001848961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026402,"about_ca_topic_score_gemma":0.001305635,"domain_scores_codex":[0.9999422,0.000002909329,0.000005782418,0.00001907886,0.00001586989,0.00001410945],"domain_scores_gemma":[0.999915,0.00001029891,0.00002008032,0.000007978537,0.00002239827,0.00002422664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003440301,0.000003351675,0.0003821037,0.0000169214,0.000006120791,0.00005387131,0.00001076782,0.0000294708,0.998987,0.00002327915,0.00001024571,0.0004424728],"study_design_scores_gemma":[0.000004380232,0.00006885756,0.02997353,0.000009183223,0.00003387715,0.0006508558,0.0000989348,0.001419084,0.9668522,0.0001112553,0.0007668379,0.00001101924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908199,0.001250735,0.006031578,0.00003800111,0.00001344368,0.00001676791,0.001142845,0.00006925187,0.0006174469],"genre_scores_gemma":[0.9865856,0.001346974,0.00853692,0.00008993351,0.000006078567,0.00005668948,0.001389335,0.0000567552,0.001931589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026402,"threshold_uncertainty_score":0.00223738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02607962526466582,"score_gpt":0.2753291936350523,"score_spread":0.2492495683703865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}