{"id":"W4388728133","doi":"10.1128/mbio.02417-23","title":"HIV reservoirs are dominated by genetically younger and clonally enriched proviruses","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; Simon Fraser University; Michael Smith Health Research BC","keywords":"Human immunodeficiency virus (HIV); Biology; Virology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225751,0.0001275794,0.000189606,0.0004049981,0.0002747083,0.0005941893,0.0001897138,0.0001997617,0.001337242],"category_scores_gemma":[0.0005335784,0.0001438324,0.0001551489,0.0002220415,0.0002129592,0.0004501469,0.0004022156,0.0003087172,0.0003190144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866325,"about_ca_system_score_gemma":0.0001619224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008724598,"about_ca_topic_score_gemma":0.001148158,"domain_scores_codex":[0.9998794,0.00001285579,0.000007511791,0.00004745163,0.00002542889,0.00002736332],"domain_scores_gemma":[0.9997092,0.00006124162,0.0001139337,0.00003462769,0.00003617103,0.00004477495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003747513,0.00007848737,0.3878334,0.00007813234,0.00007164139,0.000423318,0.0008317092,0.002656631,0.5757164,0.001294092,0.0001694639,0.03047212],"study_design_scores_gemma":[0.00001526861,0.0005139006,0.8974574,0.00005061816,0.0001181537,0.003196661,0.0007777589,0.01320367,0.07787888,0.001784144,0.004954986,0.00004853035],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978179,0.0002008886,0.001316677,0.000008687576,0.000001493772,0.000005213035,0.0001228367,0.00001989033,0.0005063564],"genre_scores_gemma":[0.9983601,0.0000671762,0.0009864728,0.00001248781,0.000002745276,0.000004114197,0.000246418,0.00001115149,0.0003093393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337242,"threshold_uncertainty_score":0.004473507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556131438024395,"score_gpt":0.2590805768340903,"score_spread":0.2435192624538464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}