{"id":"W4388728839","doi":"10.1016/j.annonc.2023.10.790","title":"VP4-2023: Sotorasib 960 mg versus 240 mg in pretreated KRAS G12C advanced NSCLC","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Amgen","keywords":"Medicine; Cmax; Internal medicine; Clinical endpoint; Gastroenterology; Pharmacokinetics; Confidence interval; Dosing; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000781901,0.0002251672,0.0007907525,0.0005501935,0.00004430827,0.000007242726,0.0002839618,0.0003725321,0.0005423154],"category_scores_gemma":[0.00192102,0.0002076543,0.0001447549,0.001698419,0.0002905319,0.0001046425,0.0002189104,0.0003959159,0.000642797],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003166196,"about_ca_system_score_gemma":0.007245569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009557938,"about_ca_topic_score_gemma":0.0006190998,"domain_scores_codex":[0.99737,0.0001804718,0.0005786569,0.0004811379,0.0005058773,0.0008838387],"domain_scores_gemma":[0.9975655,0.001040766,0.0001556481,0.0005857763,0.0003954699,0.0002568164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06040785,0.003544243,0.01157787,0.001655197,0.001517591,0.01513114,0.005274219,0.00100302,0.09257411,0.0016811,0.3317806,0.4738531],"study_design_scores_gemma":[0.3302835,0.0449135,0.06820346,0.001539871,0.0003310072,0.0004970633,0.004589845,0.01941772,0.08152863,0.002084034,0.4450994,0.001511891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497086,0.0005038232,0.00000269035,0.004566158,0.0005340041,0.000741624,0.00002206413,0.0001282714,0.04379278],"genre_scores_gemma":[0.9928858,0.001281307,0.0001506215,0.0004863132,0.0001805464,0.0001145521,0.0000998078,0.00004592029,0.004755103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4723412,"threshold_uncertainty_score":0.9983824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655893023950007,"score_gpt":0.4753252761831692,"score_spread":0.3097359737881685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}