{"id":"W4388731018","doi":"10.1186/s12964-023-01335-6","title":"Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival","year":2023,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi; Deutsche Forschungsgemeinschaft","keywords":"Biology; Chromatin; Epigenetics; Cancer research; Regulator; Cell cycle; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305874,0.0003027473,0.0002806099,0.0002442165,0.0001364724,0.0002449569,0.000276026,0.0002321831,0.001171011],"category_scores_gemma":[0.0001047119,0.0001073126,0.0002735312,0.0001451147,0.000156388,0.00008480231,0.000197873,0.0002792791,0.0003060525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872,"about_ca_system_score_gemma":0.0002535835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007749633,"about_ca_topic_score_gemma":0.002077224,"domain_scores_codex":[0.9998523,0.00001008887,0.00001427283,0.00003761626,0.00006364533,0.00002202029],"domain_scores_gemma":[0.999902,0.00001843181,0.00003729191,0.00001118294,0.00001191021,0.00001915711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004150207,0.000009732276,0.0004466845,0.00002583822,0.000006215424,0.00008585662,0.000005098913,0.00007869124,0.9981528,0.00003895503,0.00005416376,0.00105442],"study_design_scores_gemma":[0.000006322043,0.0000813509,0.004461217,0.000003191228,0.00002234696,0.000228169,0.00001141076,0.001412286,0.9922141,0.00002242843,0.001532436,0.000004783287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772448,0.0006558086,0.01651067,0.0001298521,0.00003212374,0.00007048488,0.002377002,0.0007268297,0.002252341],"genre_scores_gemma":[0.9862382,0.0003795481,0.008173788,0.00008900746,0.00000460087,0.0000536058,0.001963359,0.00006955468,0.003028374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171011,"threshold_uncertainty_score":0.003917456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714719549245132,"score_gpt":0.2786102716340199,"score_spread":0.2414630761415685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}