{"id":"W4388732355","doi":"10.3390/molecules28227619","title":"Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing β-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Mitacs","keywords":"Inflammation; Proinflammatory cytokine; Inflammasome; Chemistry; Lipopolysaccharide; Eugenol; TLR4; Cell biology; Endocrinology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153279,0.0001763079,0.0002194644,0.0001474867,0.00005128807,0.00002627532,0.0001012295,0.0001735323,0.000004321219],"category_scores_gemma":[0.00005412355,0.0001776844,0.00003356604,0.0001350623,0.00003845182,0.00001346949,0.0001350608,0.0001073654,0.000002927935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001155196,"about_ca_system_score_gemma":0.00005189362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001923684,"about_ca_topic_score_gemma":0.0001533378,"domain_scores_codex":[0.9988431,0.0001002891,0.0003234579,0.0003510009,0.0001190249,0.0002631185],"domain_scores_gemma":[0.9996194,0.000009965595,0.0001125577,0.0001549802,0.00004164274,0.00006149363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002068851,0.00005863103,0.006153875,0.0001124454,0.00001867465,0.000007919773,0.0001548051,0.00001178552,0.9930965,0.00005211925,0.00001309707,0.0002994957],"study_design_scores_gemma":[0.0007339863,0.00007706608,0.05059432,0.00006720588,0.00001270262,0.000002244898,0.0002258418,0.0001551107,0.9478905,0.00004975555,0.00001237459,0.0001788444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980559,0.001469722,0.000006115678,0.00006495774,0.0000520659,0.0002780416,0.00003622545,0.00001895515,0.00001805403],"genre_scores_gemma":[0.9991249,0.0005293162,0.00001778638,0.00003061477,0.00003870062,0.00006039846,0.000102611,0.00002867566,0.00006696017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04520592,"threshold_uncertainty_score":0.7245759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007996117290778329,"score_gpt":0.2159096893637844,"score_spread":0.207913572073006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}