{"id":"W4388732619","doi":"10.1002/jbm4.10841","title":"Increased Osteoblast <scp> Gα <sub>S</sub> </scp> Promotes Ossification by Suppressing Cartilage and Enhancing Callus Mineralization During Fracture Repair in Mice","year":2023,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Endochondral ossification; Bone healing; Osteoblast; Endocrinology; Chondrogenesis; Chemistry; Internal medicine; Cartilage; Bone remodeling; Chondrocyte; Bone fracture; Wnt signaling pathway; Cell biology; Anatomy; Biology; Medicine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003788543,0.0009542769,0.0006926199,0.001648667,0.0003026971,0.0004396954,0.0005068487,0.0009203031,0.002174413],"category_scores_gemma":[0.0001660611,0.0005556192,0.0008215843,0.0004227026,0.001165077,0.0003120117,0.0003932629,0.001723364,0.0008365836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000604186,"about_ca_system_score_gemma":0.0005206949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001611123,"about_ca_topic_score_gemma":0.002887649,"domain_scores_codex":[0.9994266,0.0000895974,0.00007087076,0.0001059496,0.0001703347,0.0001365885],"domain_scores_gemma":[0.999523,0.00004667447,0.0001910302,0.00005113327,0.0000317544,0.0001563596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004398628,0.0001037636,0.000136703,0.00002767527,0.000009193864,0.00006159452,0.00002035968,0.00006934921,0.9983774,0.0001001907,0.00005295686,0.0006009096],"study_design_scores_gemma":[0.0002247309,0.002132241,0.00651457,0.00002398993,0.00004720064,0.0004260846,0.00008397156,0.001017242,0.9872177,0.0001223318,0.002176422,0.00001346138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927229,0.0009497928,0.002956177,0.0003339475,0.00003875272,0.0001145356,0.001496195,0.0003383755,0.001049335],"genre_scores_gemma":[0.9825712,0.001090611,0.005474232,0.000233507,0.00003783015,0.0003498156,0.001456678,0.0001894929,0.00859665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002174413,"threshold_uncertainty_score":0.007274091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004957665025301605,"score_gpt":0.2156975856959267,"score_spread":0.2107399206706251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}