{"id":"W4388732699","doi":"10.3324/haematol.2023.284188","title":"First-line MAPK inhibition in pediatric histiocytosis: are we ready?","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Line (geometry); MAPK/ERK pathway; Medicine; Biology; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001486412,0.0005097864,0.001417324,0.0005746701,0.001524364,0.001951191,0.001290444,0.01715258,0.007390012],"category_scores_gemma":[0.007562066,0.0003480403,0.001231386,0.0004875092,0.001415525,0.003465867,0.0007356412,0.02130246,0.006233228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00251808,"about_ca_system_score_gemma":0.002000652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00252292,"about_ca_topic_score_gemma":0.006731544,"domain_scores_codex":[0.9990067,0.0003028262,0.0001330713,0.00007642603,0.0003103389,0.0001707127],"domain_scores_gemma":[0.996157,0.001885082,0.0002609245,0.0001133891,0.0006259194,0.0009577631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002150432,0.0001210327,0.001500357,0.0002034004,0.00004007286,0.007008367,0.00007459555,0.0002955527,0.0005617153,0.004384281,0.9163415,0.06925403],"study_design_scores_gemma":[0.0003764723,0.0002932294,0.002213969,0.001402155,0.00007699479,0.0166853,0.0003990504,0.0006077187,0.000458899,0.01689686,0.9605197,0.00006964623],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0009431317,0.02249382,0.0001654704,0.9624588,0.008835125,0.00001104616,0.00009313943,0.00005095362,0.004948497],"genre_scores_gemma":[0.02023638,0.04144715,0.001026837,0.8549938,0.0734428,0.00007499823,0.000205717,0.00005032609,0.008521832],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01715258,"threshold_uncertainty_score":0.0247221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06669837523109853,"score_gpt":0.2875293226325594,"score_spread":0.2208309474014608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}