{"id":"W4388732699","doi":"10.3324/haematol.2023.284188","title":"First-line MAPK inhibition in pediatric histiocytosis: are we ready?","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Line (geometry); MAPK/ERK pathway; Medicine; Biology; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001145259,0.0005016865,0.001226938,0.0006058326,0.0001117392,0.00002539168,0.0001020681,0.001206251,0.0003414752],"category_scores_gemma":[0.0002134014,0.0004030991,0.0002182455,0.0006196083,0.00008203372,0.00004475364,0.00008029558,0.001193028,0.002305195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279182,"about_ca_system_score_gemma":0.0001384727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009344007,"about_ca_topic_score_gemma":0.0001819105,"domain_scores_codex":[0.9974275,0.00007169397,0.0006734289,0.0007670787,0.0004771973,0.0005830789],"domain_scores_gemma":[0.9987106,0.0001856148,0.0003691257,0.0005477646,0.00009139329,0.00009551951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006524893,0.0002671377,0.004243889,0.001926932,0.00005750829,0.04633331,0.00005973095,0.000008555087,2.548455e-7,0.00003508585,0.9467569,0.0002454737],"study_design_scores_gemma":[0.005073352,0.0007394423,0.008504589,0.002727632,0.001177049,0.001499047,0.00007309151,0.0001148196,0.00002340236,0.003960238,0.9751649,0.0009424621],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01562421,0.003461751,0.00004949404,0.9703138,0.0007808093,0.001501298,0.000245802,0.0007628591,0.007259918],"genre_scores_gemma":[0.2317963,0.03557293,0.0009900786,0.6194808,0.006215056,0.002636841,0.01140731,0.0005884781,0.09131224],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3508331,"threshold_uncertainty_score":0.9998421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06669837523109853,"score_gpt":0.2875293226325594,"score_spread":0.2208309474014608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}