{"id":"W4388734014","doi":"10.1242/jcs.261138","title":"Integrin-based adhesions promote cell–cell junction and cytoskeletal remodelling to drive embryonic wound healing","year":2023,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ted Rogers Centre for Heart Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"Cell biology; Wound healing; Biology; Cell polarity; Adherens junction; Extracellular matrix; Cytoskeleton; Cell migration; Cell adhesion; Integrin; Focal adhesion; Embryonic stem cell; Myosin; Cadherin; Cell; Immunology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007964124,0.0001130711,0.0001244757,0.0002414268,0.0002485264,0.00009177008,0.0002428611,0.00006546787,0.00001255581],"category_scores_gemma":[0.00007060564,0.00009837143,0.00009908964,0.0004699285,0.00005993406,0.00002170355,0.0001005693,0.00021764,0.00002127245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004796953,"about_ca_system_score_gemma":0.0003405501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001326341,"about_ca_topic_score_gemma":0.00001304026,"domain_scores_codex":[0.9988756,0.0000294307,0.0002663485,0.0002666616,0.000290791,0.0002711501],"domain_scores_gemma":[0.9991124,0.00001973081,0.0001998841,0.0001817088,0.000258603,0.000227704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002567158,0.00004365485,0.00001774483,0.00001493801,0.00000238321,0.000006038271,0.00007854673,0.00441966,0.9945244,0.00001048694,0.0003886888,0.0004677714],"study_design_scores_gemma":[0.0002643385,0.000631871,0.00004787094,0.00003774327,0.00001542919,0.00002488245,0.0002487436,0.0330255,0.9561017,0.00007340953,0.009406134,0.0001224371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9524894,0.0001499062,0.04562519,0.0003504377,0.0005117664,0.0001112298,0.000002009761,0.000006883558,0.0007531449],"genre_scores_gemma":[0.9946436,0.0001658575,0.003858842,0.0001414606,0.0001545924,0.000001577171,0.000004029164,0.0000126799,0.001017353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04215418,"threshold_uncertainty_score":0.4011471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242363676207618,"score_gpt":0.2624667930007056,"score_spread":0.2500431562386294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}