{"id":"W4388734777","doi":"10.3390/cancers15225439","title":"Ring Chromosomes in Hematological Malignancies Are Associated with TP53 Gene Mutations and Characteristic Copy Number Variants","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Human Genome Research Institute; Johns Hopkins University","keywords":"Karyotype; Biology; Cancer; Chromosome; Chromosome instability; Myeloid; Gene; Cancer research; Chromosomal translocation; Mutation; Genetics; Ring chromosome; Gene mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002191874,0.000182315,0.000154617,0.00120589,0.0001652524,0.0002745083,0.0001736155,0.0001684875,0.00179422],"category_scores_gemma":[0.001091089,0.0001087342,0.0001081616,0.000546321,0.0002641706,0.0001406267,0.0002377175,0.0001305596,0.0001898148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001270255,"about_ca_system_score_gemma":0.00007289561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005502732,"about_ca_topic_score_gemma":0.001070254,"domain_scores_codex":[0.99984,0.00003074287,0.00001867036,0.00004187119,0.00004398542,0.00002462838],"domain_scores_gemma":[0.9994236,0.0001722531,0.0002538887,0.00005259103,0.00004032771,0.00005734413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005330649,0.00002468587,0.9224238,0.0000399769,0.00007603412,0.002837881,0.000153909,0.0002878153,0.05134753,0.0002589571,0.0003672479,0.02164905],"study_design_scores_gemma":[0.00002659114,0.0001111168,0.9693115,0.00001232204,0.00005878778,0.01652615,0.0001000447,0.0006288932,0.0117864,0.0001988162,0.001231271,0.00000802458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987054,0.0003354104,0.0002888345,0.00002239431,0.0000023441,0.000005340753,0.0001106358,0.00001652006,0.0005131359],"genre_scores_gemma":[0.9993376,0.0001289155,0.0002849691,0.000008209478,0.000005583992,0.000002952922,0.0001040783,0.000002407589,0.0001252653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179422,"threshold_uncertainty_score":0.006002247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175380485967436,"score_gpt":0.3061054503729914,"score_spread":0.274351645513317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}