{"id":"W4388735893","doi":"10.1016/j.molcel.2023.10.017","title":"Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition","year":2023,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Hospital for Sick Children; SickKids Foundation; University of Toronto; Université de Montréal; McGill University","funders":"Cancer Research UK","keywords":"Biology; Cyclin-dependent kinase; Senescence; Cell growth; PI3K/AKT/mTOR pathway; Cell biology; Cyclin-dependent kinase 7; Growth inhibition; Cancer cell; Signal transduction; Cell cycle; Cancer research; Mechanistic target of rapamycin; Kinase; Cancer; Genetics; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001314643,0.0002746586,0.000298071,0.0003263325,0.0002121202,0.0004891747,0.0001641362,0.000221344,0.001481303],"category_scores_gemma":[0.0001339198,0.0001380515,0.0002490415,0.0002000423,0.0002469127,0.0002280483,0.0002304716,0.0004520075,0.0005241725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600425,"about_ca_system_score_gemma":0.0002497466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005527802,"about_ca_topic_score_gemma":0.0009198223,"domain_scores_codex":[0.9998479,0.00001850047,0.00001328645,0.00003395425,0.00005002699,0.00003638933],"domain_scores_gemma":[0.9998661,0.00001849855,0.00004379899,0.00001621101,0.00001986288,0.0000355044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008008303,0.00001966478,0.0004991985,0.00003361548,0.000005194671,0.00004653749,0.000008521417,0.00006810093,0.9971203,0.0001917623,0.00007157466,0.001855342],"study_design_scores_gemma":[0.000006768805,0.0001269791,0.006880112,0.00000588314,0.00000793347,0.0002690191,0.0000163416,0.0004921141,0.9890766,0.0001096089,0.003004993,0.000003656689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838929,0.006810281,0.002964052,0.0002827433,0.00004621221,0.00002355045,0.0004935196,0.0002434631,0.005243336],"genre_scores_gemma":[0.9959168,0.001343775,0.0008534142,0.00007150069,0.00001173037,0.00001160226,0.0002663615,0.00002027503,0.001504521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481303,"threshold_uncertainty_score":0.004955411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007225262592089179,"score_gpt":0.2284214091620343,"score_spread":0.2211961465699452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}