{"id":"W4388735893","doi":"10.1016/j.molcel.2023.10.017","title":"Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition","year":2023,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Hospital for Sick Children; SickKids Foundation; University of Toronto; Université de Montréal; McGill University","funders":"Cancer Research UK","keywords":"Biology; Cyclin-dependent kinase; Senescence; Cell growth; PI3K/AKT/mTOR pathway; Cell biology; Cyclin-dependent kinase 7; Growth inhibition; Cancer cell; Signal transduction; Cell cycle; Cancer research; Mechanistic target of rapamycin; Kinase; Cancer; Genetics; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155598,0.0001527724,0.0001050333,0.00004853025,0.00008607655,0.00003154757,0.00004554829,0.0001073578,0.00001158717],"category_scores_gemma":[0.00004473239,0.0001604545,0.00005014121,0.0001932788,0.00003535847,0.000008462397,0.000131726,0.00007092052,0.00002736759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002172922,"about_ca_system_score_gemma":0.00004571046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001301008,"about_ca_topic_score_gemma":0.00003028613,"domain_scores_codex":[0.9990039,0.00009233603,0.000119182,0.0004055444,0.0001424491,0.0002365624],"domain_scores_gemma":[0.9995592,0.000008819046,0.00005110521,0.0001645209,0.00009716947,0.0001192061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002495453,0.00002650336,0.0001644092,0.00003812183,0.000007048726,0.00002797077,0.00008716925,0.00005537191,0.9972202,0.00001217622,0.0005877878,0.001748313],"study_design_scores_gemma":[0.0002491766,0.0001019434,0.0002734291,0.00002360388,0.00001023206,0.000002927008,0.00008268608,0.0001382691,0.9971543,0.00003976561,0.001715502,0.000208181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924964,0.0002637537,0.005414921,0.0003546253,0.00007851072,0.000332804,0.00003042637,0.00004234672,0.0009862544],"genre_scores_gemma":[0.9981399,0.0001325325,0.0005067158,0.0005529407,0.00008634604,0.00004638638,0.0001047098,0.00002674729,0.0004036826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005643581,"threshold_uncertainty_score":0.6543145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007225262592089179,"score_gpt":0.2284214091620343,"score_spread":0.2211961465699452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}