{"id":"W4388747498","doi":"10.3390/antib12040075","title":"Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor","year":2023,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Diamond Light Source; Medical Research Council Canada; Wellcome Trust","keywords":"Paratope; Immunoglobulin D; Antibody; Idiotype; Molecular biology; Immunoglobulin Idiotypes; Immunoglobulin Fab Fragments; Monoclonal antibody; Isotype; Recombinant DNA; Antigen; Hybridoma technology; Epitope; Biology; Chemistry; Virology; Immunology; Complementarity determining region; Genetics; B cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003798491,0.0004651676,0.0003492318,0.0004156784,0.0001498024,0.0004429697,0.0006704709,0.0004781295,0.001242509],"category_scores_gemma":[0.0001942354,0.000243987,0.0004390878,0.000161306,0.000280907,0.0003245748,0.0006538879,0.001081743,0.0008733339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459997,"about_ca_system_score_gemma":0.0003081641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771544,"about_ca_topic_score_gemma":0.0005170341,"domain_scores_codex":[0.9997482,0.00002543739,0.00001561266,0.00004313284,0.0001183304,0.00004925423],"domain_scores_gemma":[0.9998689,0.00002168811,0.00002238506,0.00001807308,0.0000273266,0.00004161035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004788703,0.00004437532,0.0001664961,0.00005522191,0.00001317875,0.00006862072,0.00001668909,0.0002487586,0.9922123,0.000435843,0.0002602646,0.006430488],"study_design_scores_gemma":[0.00006669274,0.0004267633,0.001031438,0.00001541346,0.00005139853,0.00075017,0.00001577569,0.00263847,0.9614295,0.0001852486,0.03337349,0.0000156707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.82649,0.00671599,0.1496438,0.0009305045,0.0002296438,0.0007233747,0.001325471,0.001684291,0.01225681],"genre_scores_gemma":[0.830202,0.005334476,0.1501949,0.001049531,0.00006526516,0.000487065,0.002547042,0.000265949,0.009853732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242509,"threshold_uncertainty_score":0.004156649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04780262632180483,"score_gpt":0.3791458369127469,"score_spread":0.3313432105909421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}