{"id":"W4388747498","doi":"10.3390/antib12040075","title":"Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor","year":2023,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Diamond Light Source; Medical Research Council Canada; Wellcome Trust","keywords":"Paratope; Immunoglobulin D; Antibody; Idiotype; Molecular biology; Immunoglobulin Idiotypes; Immunoglobulin Fab Fragments; Monoclonal antibody; Isotype; Recombinant DNA; Antigen; Hybridoma technology; Epitope; Biology; Chemistry; Virology; Immunology; Complementarity determining region; Genetics; B cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008689187,0.0004408651,0.0007075231,0.0004266266,0.0009717926,0.0001879772,0.0004789423,0.000189908,0.0003145772],"category_scores_gemma":[0.0002426707,0.0002785734,0.0003158544,0.001135011,0.0005776124,0.0004014889,0.0003991275,0.0005858895,0.001562172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004093306,"about_ca_system_score_gemma":0.0001793674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357102,"about_ca_topic_score_gemma":0.00002933313,"domain_scores_codex":[0.9964822,0.0001705485,0.0005425986,0.0006904583,0.0009958111,0.001118367],"domain_scores_gemma":[0.9981772,0.0003194697,0.000120168,0.0008027813,0.0002610584,0.0003192767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002982705,0.0003087881,0.4747285,0.0003795595,0.0003566173,0.0009335087,0.00155189,0.000018451,0.4877889,0.002307502,0.02424192,0.007086093],"study_design_scores_gemma":[0.001293391,0.0007905901,0.8433131,0.0004222291,0.0001541292,0.0003866405,0.002152984,0.0007643955,0.08342507,0.0004748045,0.06612338,0.0006992878],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840382,0.00128146,0.00001775512,0.006515011,0.0008563267,0.0005749995,0.00006284374,0.0004781992,0.006175169],"genre_scores_gemma":[0.9835849,0.004835905,0.0001829081,0.0008060571,0.001504665,0.00002154183,0.0004538436,0.0000804476,0.00852976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4043638,"threshold_uncertainty_score":0.9999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04780262632180483,"score_gpt":0.3791458369127469,"score_spread":0.3313432105909421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}