{"id":"W4388751802","doi":"10.1182/blood.2023022052","title":"Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Kynurenine; Biology; Indoleamine 2,3-dioxygenase; Population; Immunology; Biochemistry; Medicine; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005799112,0.0002232605,0.0002656253,0.0001720115,0.0001750432,0.0006952023,0.0001855342,0.0002195729,0.001791151],"category_scores_gemma":[0.0005352387,0.0001228718,0.000221469,0.0001867908,0.0002249712,0.0002147904,0.0002942535,0.000268761,0.0002350025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865009,"about_ca_system_score_gemma":0.0002611196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103765,"about_ca_topic_score_gemma":0.001236056,"domain_scores_codex":[0.9996029,0.0001473079,0.00003640644,0.00009260201,0.00007424733,0.00004658001],"domain_scores_gemma":[0.9996828,0.00005713985,0.0001204572,0.00005351201,0.00004160836,0.00004447069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001618926,0.0001977256,0.1376923,0.00009007783,0.0002009769,0.0001162498,0.0002083928,0.0002625196,0.8510451,0.0001787147,0.0001788544,0.008210127],"study_design_scores_gemma":[0.00004519562,0.001140216,0.690949,0.0000326959,0.0001684312,0.0005561917,0.0003083227,0.002303795,0.3028614,0.0002400827,0.001375129,0.00001965452],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983934,0.000524799,0.0005347021,0.00003330785,0.000006486264,0.000009697798,0.0002806278,0.000006094607,0.0002110364],"genre_scores_gemma":[0.9987642,0.0001584633,0.0004195724,0.00003714747,0.000003152865,0.00001164175,0.0002728965,0.000004125664,0.0003289944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791151,"threshold_uncertainty_score":0.005991995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337796823804639,"score_gpt":0.2474730900624144,"score_spread":0.2340951218243681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}