{"id":"W4388751802","doi":"10.1182/blood.2023022052","title":"Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Kynurenine; Biology; Indoleamine 2,3-dioxygenase; Population; Immunology; Biochemistry; Medicine; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320209,0.000103323,0.0003520788,0.0002579663,0.00001409609,0.000002655334,0.00002459994,0.0001435786,0.00003176428],"category_scores_gemma":[0.00005249394,0.00009224142,0.00002702512,0.0003799223,0.0000621401,0.00002084454,0.00003386697,0.00009531469,0.000001586662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004108306,"about_ca_system_score_gemma":0.00002222268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006094986,"about_ca_topic_score_gemma":0.00003102296,"domain_scores_codex":[0.999244,0.0000675656,0.0002516131,0.0002179884,0.00004812384,0.0001706565],"domain_scores_gemma":[0.9996205,0.00006526476,0.00007683376,0.0001423269,0.00002792954,0.00006714027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002321474,0.0002103051,0.02612583,0.00006507056,0.00002950885,0.000006436997,0.0001572277,0.000002539128,0.9726843,0.000006087731,0.0001370122,0.0003435957],"study_design_scores_gemma":[0.006729087,0.0002175873,0.2776297,0.00001809956,0.0001743154,0.00002357645,0.00004491059,0.0001868859,0.7143232,0.0001649224,0.0004073265,0.00008034207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973027,0.002010042,0.000003546253,0.0002620361,0.00005203169,0.0001620238,0.000029984,0.00002104155,0.000156623],"genre_scores_gemma":[0.9973949,0.001722582,0.0004476035,0.00009286367,0.00005313109,0.000008622971,0.00008681228,0.0000117696,0.0001817157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.258361,"threshold_uncertainty_score":0.3761496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337796823804639,"score_gpt":0.2474730900624144,"score_spread":0.2340951218243681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}