{"id":"W4388753588","doi":"10.1056/evidoa2200325","title":"RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia","year":2023,"lang":"en","type":"article","venue":"NEJM Evidence","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université de Montréal","funders":"","keywords":"Hypertriglyceridemia; Apolipoprotein B; RNA interference; Medicine; Interference (communication); Cancer research; Internal medicine; RNA; Chemistry; Biochemistry; Cholesterol; Computer science; Triglyceride; Telecommunications; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004304578,0.000286675,0.0003562304,0.0001786402,0.0001348281,0.0001509417,0.0001790353,0.0002995704,0.001222658],"category_scores_gemma":[0.0003192097,0.00007247302,0.0002360773,0.0001517102,0.0002361104,0.0000851389,0.0001063697,0.0005113934,0.0001769799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002748808,"about_ca_system_score_gemma":0.0002839075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002794339,"about_ca_topic_score_gemma":0.0006875988,"domain_scores_codex":[0.9998566,0.00005064455,0.00001388785,0.00001969303,0.00003558053,0.00002350494],"domain_scores_gemma":[0.999856,0.00005343855,0.00004428869,0.000008573546,0.0000138885,0.00002374118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08889852,0.007558692,0.01057224,0.00129436,0.0005460819,0.0007689866,0.0001909712,0.001552381,0.4969402,0.0005404687,0.002722625,0.3884144],"study_design_scores_gemma":[0.1014645,0.4243243,0.09900199,0.0002909197,0.001688923,0.005981232,0.0002120035,0.008601866,0.3287683,0.001085541,0.0285017,0.00007884692],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904198,0.005299624,0.001717984,0.0002354326,0.00007757792,0.0004431879,0.0001188451,0.00008097689,0.001606645],"genre_scores_gemma":[0.9937516,0.002019724,0.002472576,0.0003265254,0.00006646418,0.0003917212,0.0001678105,0.000007939854,0.0007956925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222658,"threshold_uncertainty_score":0.00409025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0708745473908623,"score_gpt":0.3328108356171358,"score_spread":0.2619362882262735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}