{"id":"W4388756448","doi":"10.1101/2023.11.15.567229","title":"LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Endocrinology; Internal medicine; Cholecystokinin; Parvalbumin; Prefrontal cortex; Somatostatin; GABAergic; Hippocampus; Neuropeptide Y receptor; Brain-derived neurotrophic factor; Interneuron; Neurotrophic factors; Neuropeptide; Vasoactive intestinal peptide; Inflammation; Biology; Medicine; Neuroscience; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000978689,0.000574667,0.0003396687,0.0004190183,0.0001164936,0.0002735831,0.0001468638,0.0002736431,0.001060138],"category_scores_gemma":[0.00008496038,0.0002563934,0.0002720075,0.0001383914,0.0002890203,0.0001687203,0.0001712292,0.0008729713,0.0002781646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743878,"about_ca_system_score_gemma":0.0002992512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001507126,"about_ca_topic_score_gemma":0.002858409,"domain_scores_codex":[0.9998548,0.00001084922,0.00001263503,0.00004231556,0.00003322555,0.00004617647],"domain_scores_gemma":[0.9997761,0.000008132396,0.0001039793,0.00001140462,0.00002307742,0.0000773664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003199013,0.00003931078,0.0002683329,0.00002503394,0.000005228945,0.00002021302,0.000009744522,0.00002125746,0.9988942,0.000008908063,0.00001662069,0.0003713981],"study_design_scores_gemma":[0.00009333024,0.001908238,0.03805338,0.00003079695,0.00005726646,0.0002608936,0.000126737,0.0006066302,0.9579543,0.00007847316,0.0008184246,0.00001161874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996393,0.001163709,0.001052354,0.00008875583,0.00003261802,0.00001986393,0.0007635319,0.00007930485,0.0004068317],"genre_scores_gemma":[0.9924945,0.001339579,0.002154889,0.0001136927,0.00001584959,0.0000916567,0.000794176,0.00003191714,0.00296362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507126,"threshold_uncertainty_score":0.003546476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523347093854862,"score_gpt":0.2351304526452912,"score_spread":0.2098969817067426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}