{"id":"W4388757474","doi":"10.21203/rs.3.rs-3420578/v1","title":"Dependence of Human Cell Survival and Proliferation on the CASP3 Prodomain","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Provincial Health Services Authority; Terry Fox Research Institute; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Cell growth; Cell; Cell biology; Cell survival; Cancer research; Biology; Chemistry; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137041,0.0001702046,0.0001219274,0.0001380764,0.0000820441,0.0002063957,0.00009469242,0.0001114832,0.001422209],"category_scores_gemma":[0.0001051618,0.00005094027,0.0000989089,0.0001036022,0.0001268489,0.00008485861,0.0001148267,0.0002251384,0.0004536689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016738,"about_ca_system_score_gemma":0.0001475894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000842263,"about_ca_topic_score_gemma":0.0008815415,"domain_scores_codex":[0.9998964,0.00001773638,0.00001018039,0.00002322708,0.00003604659,0.00001646903],"domain_scores_gemma":[0.9998993,0.00004807305,0.00001471564,0.00001433125,0.00001350833,0.0000101589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021818,0.00001608676,0.0001299048,0.00001342908,0.000002231466,0.00002857873,0.000009844224,0.0000660376,0.9979792,0.00008901199,0.00004218115,0.00152126],"study_design_scores_gemma":[0.00000404584,0.0001179978,0.001777822,0.000001718215,0.000003543315,0.00009188324,0.000007031404,0.0004450902,0.996233,0.00002994787,0.001286231,0.000001568573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881441,0.001898346,0.004807865,0.0000861199,0.00002400054,0.00003013669,0.0008527603,0.0001484985,0.004008224],"genre_scores_gemma":[0.9940048,0.0004925274,0.002097087,0.00003187974,0.000003513042,0.00003342781,0.0007925194,0.00002046746,0.002523819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422209,"threshold_uncertainty_score":0.004757702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06740776724668612,"score_gpt":0.4179824753156534,"score_spread":0.3505747080689673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}