{"id":"W4388760551","doi":"10.3390/diagnostics13223464","title":"Diagnostic Insights into Pediatric Pleomorphic Xanthoastrocytoma through DNA Methylation Class and Pathological Diagnosis Analysis","year":2023,"lang":"en","type":"article","venue":"Diagnostics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pleomorphic xanthoastrocytoma; Pilocytic astrocytoma; CDKN2A; Astrocytoma; Pathological; Pathology; DNA methylation; Methylation; Glioma; Differential diagnosis; Biology; Medicine; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002612531,0.0004727004,0.0009324967,0.0008608804,0.0003130164,0.00009422788,0.0001432575,0.0003242719,0.000117722],"category_scores_gemma":[0.005656848,0.0003845593,0.0003405083,0.00368956,0.0001743679,0.0001831838,0.0002175,0.0002976626,0.0003288197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263905,"about_ca_system_score_gemma":0.00006918261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009213855,"about_ca_topic_score_gemma":0.0001277409,"domain_scores_codex":[0.9970699,0.0001866956,0.000653946,0.0008498756,0.0006412306,0.0005983337],"domain_scores_gemma":[0.9907089,0.007884483,0.0002205499,0.0005824675,0.0002214488,0.0003821654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000346121,0.0007510163,0.9860665,0.0001033791,0.0006014351,0.00295849,0.0009159862,0.0002507302,0.0001118068,0.001070049,0.004020767,0.003115286],"study_design_scores_gemma":[0.001927968,0.0007246874,0.981912,0.00006165077,0.006473397,0.00003553078,0.0002288506,0.00113781,0.002455804,0.001923751,0.002716841,0.0004016761],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990332,0.005360363,0.0004028291,0.0021921,0.000262952,0.0008369019,0.00006668404,0.000381567,0.000164609],"genre_scores_gemma":[0.9517325,0.04474256,0.001086007,0.0004999871,0.0003884335,0.0007716587,0.0007069142,0.00005299887,0.00001893056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0393822,"threshold_uncertainty_score":0.9998606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741563505439177,"score_gpt":0.2911171871382308,"score_spread":0.263701552083839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}