{"id":"W4388760551","doi":"10.3390/diagnostics13223464","title":"Diagnostic Insights into Pediatric Pleomorphic Xanthoastrocytoma through DNA Methylation Class and Pathological Diagnosis Analysis","year":2023,"lang":"en","type":"article","venue":"Diagnostics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pleomorphic xanthoastrocytoma; Pilocytic astrocytoma; CDKN2A; Astrocytoma; Pathological; Pathology; DNA methylation; Methylation; Glioma; Differential diagnosis; Biology; Medicine; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006935707,0.0002121999,0.0002054813,0.002144061,0.0002206411,0.0006201119,0.0002808237,0.0002453215,0.0009415523],"category_scores_gemma":[0.002465479,0.0001339105,0.0001660271,0.0008951319,0.0002035114,0.0004213025,0.0005596261,0.0002916118,0.000258526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932168,"about_ca_system_score_gemma":0.0003214234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001720516,"about_ca_topic_score_gemma":0.002757616,"domain_scores_codex":[0.9995327,0.0001094055,0.00005047041,0.0001327267,0.0001117222,0.00006287845],"domain_scores_gemma":[0.9992239,0.0002116862,0.0002546014,0.0000794627,0.000151608,0.00007874586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001563819,0.00001730761,0.9280143,0.00004644469,0.00003647482,0.0007837239,0.0002689934,0.0003944487,0.01096626,0.0004084656,0.0003094304,0.05859769],"study_design_scores_gemma":[0.000009572028,0.000118991,0.9587584,0.00006796474,0.0001597895,0.009468797,0.0008312861,0.01154923,0.01047876,0.002265175,0.006269048,0.0000229855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859003,0.001396304,0.009688207,0.0001743763,0.00001251041,0.00005049624,0.0006766645,0.00006406253,0.002037083],"genre_scores_gemma":[0.9921439,0.0003889916,0.006722175,0.00003581366,0.0000170468,0.00002281845,0.0004396641,0.00001536093,0.000214224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144061,"threshold_uncertainty_score":0.00366801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741563505439177,"score_gpt":0.2911171871382308,"score_spread":0.263701552083839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}