{"id":"W4388765999","doi":"10.1038/s41398-023-02646-5","title":"eIF4E phosphorylation mediated LPS induced depressive-like behaviors via ameliorated neuroinflammation and dendritic loss","year":2023,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Sanming Project of Medicine in Shenzhen; Shenzhen-Hong Kong Institute of Brain Science; National Natural Science Foundation of China","keywords":"Tropomyosin receptor kinase B; Neuroinflammation; Synaptic plasticity; Dendritic spine; Neuroscience; Brain-derived neurotrophic factor; Signal transduction; Neurotrophin; Neurotrophic factors; Medicine; Cell biology; Internal medicine; Receptor; Psychology; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449049,0.0005035237,0.0005264786,0.0002960485,0.0002017215,0.0002065579,0.0002128518,0.0004239222,0.001658855],"category_scores_gemma":[0.0001676153,0.000133217,0.000530875,0.0001445341,0.0002783063,0.0002695809,0.0002275605,0.001103163,0.0003366077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425261,"about_ca_system_score_gemma":0.0003486094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006017069,"about_ca_topic_score_gemma":0.001018552,"domain_scores_codex":[0.9998353,0.00001797351,0.00003086417,0.00003215768,0.00003391217,0.00004980177],"domain_scores_gemma":[0.9998902,0.000009200685,0.00003650579,0.00001196127,0.00002067747,0.0000314914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001209824,0.0001164082,0.0004436869,0.0002541523,0.00002178856,0.0001393808,0.00002072696,0.0001207356,0.9943584,0.00009492377,0.0001493819,0.003070713],"study_design_scores_gemma":[0.0001474121,0.00172571,0.0146595,0.00005837974,0.00007183599,0.0003976306,0.0001000563,0.001245557,0.9770954,0.0002672992,0.004212385,0.00001871193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849396,0.003842675,0.005749173,0.0005531655,0.0002254074,0.0001157617,0.002435644,0.000257564,0.001881081],"genre_scores_gemma":[0.9881828,0.002433926,0.004105208,0.000267635,0.00004064852,0.0001897302,0.001774397,0.00003934079,0.002966222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658855,"threshold_uncertainty_score":0.005549431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02290099429786005,"score_gpt":0.2691861700830741,"score_spread":0.246285175785214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}