{"id":"W4388767441","doi":"10.1101/2023.11.15.567290","title":"Neuronal exosomes transport a miRNA/RISC cargo to preserve germline stem cell integrity during energy stress","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Argonaute; Microvesicles; Biology; microRNA; Cell biology; Germline; Serotonergic; Endosome; Exosome; RNA interference; Intracellular; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246227,0.0001964895,0.0002185365,0.0001956074,0.0002584035,0.0004108828,0.0001641357,0.0003755202,0.002186825],"category_scores_gemma":[0.0002376675,0.0001157572,0.0002196296,0.0001116782,0.000232285,0.0002878716,0.0003766691,0.0004414761,0.001259106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520898,"about_ca_system_score_gemma":0.0002024759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001670521,"about_ca_topic_score_gemma":0.0002460416,"domain_scores_codex":[0.999886,0.00001372234,0.0000112409,0.00002112482,0.00005120802,0.00001661775],"domain_scores_gemma":[0.9998679,0.00002784408,0.00002869082,0.00002353042,0.00002584328,0.00002614218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008562385,0.000008139941,0.0003698568,0.00004276412,0.000004714717,0.0001778523,0.00002484113,0.00006461433,0.996024,0.0005573321,0.0004714857,0.002168768],"study_design_scores_gemma":[0.0000116435,0.00006763546,0.003581031,0.000007778912,0.000006360829,0.0005590754,0.00002908366,0.001109983,0.9866501,0.0003725627,0.007597652,0.000006968763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625971,0.003278899,0.02111191,0.001309707,0.0008234961,0.0000709181,0.001360095,0.0007236227,0.008724274],"genre_scores_gemma":[0.9713961,0.001124021,0.008555585,0.0002261046,0.0001197075,0.00004854958,0.000937963,0.0001883443,0.01740354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186825,"threshold_uncertainty_score":0.007315695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420943523626764,"score_gpt":0.2212499363746971,"score_spread":0.2070405011384294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}