{"id":"W4388767474","doi":"10.1113/jp285265","title":"Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults","year":2023,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada); International Collaboration On Repair Discoveries; University of British Columbia; University of Guelph; Vancouver Coastal Health; University of British Columbia, Okanagan Campus; Interior Health; University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; Foundation for the National Institutes of Health","keywords":"Microvesicle; Hyperthermia; Hypocapnia; Cerebral blood flow; Anesthesia; Medicine; Middle cerebral artery; Cerebral arteries; Internal medicine; Microvesicles; Endocrinology; Hypercapnia; Chemistry; Ischemia; Acidosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008178663,0.0002402745,0.0002670092,0.0002656965,0.0001724923,0.0002789329,0.00007954502,0.000356563,0.001472243],"category_scores_gemma":[0.0003955463,0.0002181817,0.0001469478,0.0001158089,0.0001855321,0.0001815185,0.000149396,0.0002837316,0.0002611883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064225,"about_ca_system_score_gemma":0.00007601696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092681,"about_ca_topic_score_gemma":0.001421466,"domain_scores_codex":[0.9999275,0.000009145948,0.000005026404,0.00002105815,0.00001564334,0.00002163299],"domain_scores_gemma":[0.999808,0.0000248364,0.0000713409,0.000007140839,0.00001658258,0.00007202753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005027016,0.000590519,0.8837194,0.00009929727,0.000139963,0.002678422,0.0008808316,0.00007143689,0.09783584,0.00005105773,0.0003936267,0.008512557],"study_design_scores_gemma":[0.00001161999,0.0007467365,0.9977095,0.000002093302,0.00002084443,0.0006725594,0.00007181415,0.00004105973,0.000639861,0.00000563159,0.00007624735,0.000002006263],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995783,0.0001301683,0.00004293322,0.00001184206,0.000003971141,0.000005902228,0.00005353081,0.000003018928,0.0001702819],"genre_scores_gemma":[0.9996561,0.00005478117,0.00002401252,0.00001609981,0.000007547032,0.000005766074,0.00005895029,8.875442e-7,0.0001759024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472243,"threshold_uncertainty_score":0.004925132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00967801682126973,"score_gpt":0.2475051279109323,"score_spread":0.2378271110896626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}