{"id":"W4388769334","doi":"10.1002/biot.202300232","title":"Successful reversal of transgene silencing in <i>Chlamydomonas reinhardtii</i>","year":2023,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Algal biology and biofuel production","field":"Energy","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Research Chairs","keywords":"Chlamydomonas reinhardtii; Biology; Transgene; Gene silencing; Histone deacetylase inhibitor; Vorinostat; Cell cycle; Molecular biology; Histone deacetylase; Epigenetics; Gene expression; Chlamydomonas; Cell biology; Gene; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007123589,0.0001315237,0.0002587315,0.0005613958,0.0001083242,0.000006371809,0.0003058233,0.0006740747,0.0001258459],"category_scores_gemma":[0.0001566263,0.0001136011,0.00009094769,0.0009373334,0.0002616907,0.0001095741,0.00005263724,0.0007480381,0.00009986125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005536802,"about_ca_system_score_gemma":0.0000579348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343592,"about_ca_topic_score_gemma":0.0001572154,"domain_scores_codex":[0.9987269,0.0001008932,0.0004485708,0.0002419531,0.0001230388,0.0003586685],"domain_scores_gemma":[0.9994832,0.00003981572,0.0001754107,0.0002112219,0.00005224725,0.00003811839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001740917,0.00005164318,0.01029348,0.00002761913,0.00005940021,0.000183276,0.0001495356,0.0003384197,0.9518093,0.00449871,0.001011272,0.03140321],"study_design_scores_gemma":[0.0009659221,0.0002568695,0.009747775,0.00007020944,0.0000233975,0.0006573478,0.0005702854,0.0001022309,0.9666907,0.009712969,0.01097754,0.0002247768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924806,0.0005515298,0.0001415663,0.005331752,0.0006789728,0.00006605418,0.000003673945,0.0001804911,0.0005653879],"genre_scores_gemma":[0.9978899,0.00128464,0.0003491541,0.00006592966,0.0001905346,0.000003341722,0.00000682711,0.00001325141,0.0001964165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03117843,"threshold_uncertainty_score":0.5199082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501885384892898,"score_gpt":0.2425070723355079,"score_spread":0.227488218486579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}