{"id":"W4388769334","doi":"10.1002/biot.202300232","title":"Successful reversal of transgene silencing in <i>Chlamydomonas reinhardtii</i>","year":2023,"lang":"en","type":"article","venue":"Biotechnology Journal","topic":"Algal biology and biofuel production","field":"Energy","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Research Chairs","keywords":"Chlamydomonas reinhardtii; Biology; Transgene; Gene silencing; Histone deacetylase inhibitor; Vorinostat; Cell cycle; Molecular biology; Histone deacetylase; Epigenetics; Gene expression; Chlamydomonas; Cell biology; Gene; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003850822,0.0005469733,0.0004767306,0.0002067337,0.000247527,0.0003945871,0.0004592807,0.0003510463,0.0005787795],"category_scores_gemma":[0.0002412912,0.0002070256,0.0004245409,0.0002018558,0.0002740567,0.0001679835,0.0004864763,0.0007936187,0.0004649152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004636178,"about_ca_system_score_gemma":0.0003286779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002520069,"about_ca_topic_score_gemma":0.002619819,"domain_scores_codex":[0.9996574,0.00003907876,0.00004306678,0.00009846349,0.00007736991,0.00008474681],"domain_scores_gemma":[0.9996964,0.00006223608,0.00008085702,0.00007459838,0.00004125438,0.0000448256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007006967,0.000003906896,0.00004632522,0.00001010885,0.000001868183,0.00001406663,0.000008232198,0.00001588186,0.9995053,0.00002624106,0.00001513963,0.0003458692],"study_design_scores_gemma":[0.00000244448,0.00005040681,0.002156233,0.000003700222,0.000008948548,0.00006247478,0.00001995268,0.0003747309,0.9956688,0.00001759997,0.001629618,0.000005134839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827747,0.001167899,0.01169497,0.0001949194,0.0000868301,0.00008219019,0.00144408,0.0005862734,0.001968167],"genre_scores_gemma":[0.9873001,0.0005650443,0.006025036,0.00008892383,0.000008754849,0.00005944044,0.001480084,0.0002163721,0.004256286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520069,"threshold_uncertainty_score":0.005010843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501885384892898,"score_gpt":0.2425070723355079,"score_spread":0.227488218486579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}