{"id":"W4388773640","doi":"10.1101/2023.11.16.567456","title":"An enterococcal phage protein broadly inhibits type IV restriction enzymes involved in antiphage defense","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institutes of Health; National Science Foundation","keywords":"Restriction enzyme; Enzyme; Microbiology; Biology; Chemistry; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688896,0.0003109862,0.0002586406,0.0001971232,0.00009822015,0.0003742424,0.0002079989,0.0003379345,0.001723714],"category_scores_gemma":[0.0001456733,0.0001077767,0.0002561407,0.0001338275,0.000203465,0.0001152665,0.0002194393,0.000502881,0.0005897178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392788,"about_ca_system_score_gemma":0.0001997375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005257078,"about_ca_topic_score_gemma":0.0005073067,"domain_scores_codex":[0.999813,0.00003039188,0.00001608653,0.00003037036,0.00006677609,0.0000434283],"domain_scores_gemma":[0.999872,0.00003169207,0.00003429273,0.0000178725,0.00001653484,0.00002759333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002786947,0.00001591319,0.0001797117,0.00001078882,0.000003476467,0.00001345566,0.000002456025,0.00003069281,0.9991033,0.00005768012,0.00003186888,0.0005228317],"study_design_scores_gemma":[0.000005495453,0.0001146567,0.002063493,0.000003432689,0.000006232363,0.0001387939,0.00001082674,0.0005104078,0.9952753,0.00002779204,0.001842012,0.00000151983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866014,0.001521638,0.007137097,0.0001890783,0.00004037228,0.00003332262,0.0003810004,0.0001327068,0.003963369],"genre_scores_gemma":[0.9905316,0.0004306788,0.003569603,0.0001134802,0.00000894017,0.0000169696,0.0006579043,0.00003844887,0.004632326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723714,"threshold_uncertainty_score":0.005766392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856946560157543,"score_gpt":0.2364583235243393,"score_spread":0.2178888579227639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}