{"id":"W4388776339","doi":"10.1016/j.omtn.2023.102080","title":"Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; University of Massachusetts Medical School; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Aldeyra Therapeutics; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Centre québécois sur les matériaux fonctionnels","keywords":"Conjugate; Oligonucleotide; Drug delivery; In vivo; Small interfering RNA; Nucleic acid; Chemistry; Amphiphile; Gene silencing; Drug carrier; Albumin; Gene delivery; Serum albumin; Pharmacology; Biophysics; Biochemistry; Biology; RNA; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002343433,0.0002876933,0.0002027485,0.000157615,0.000125823,0.0002894946,0.0001726004,0.0003399421,0.0005729052],"category_scores_gemma":[0.0002494241,0.0001298296,0.0001170472,0.000108072,0.0001710007,0.0001826052,0.0002447921,0.0003397461,0.0003932514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003018806,"about_ca_system_score_gemma":0.0002558556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003279024,"about_ca_topic_score_gemma":0.000495659,"domain_scores_codex":[0.9998709,0.00002911805,0.0000114179,0.00002135961,0.00004836069,0.00001880444],"domain_scores_gemma":[0.9998707,0.00001933426,0.00004333647,0.000008432221,0.00003058391,0.00002749615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006759453,0.00001562083,0.00008579493,0.00003872764,0.000002490483,0.00003810232,0.00000622962,0.00005134392,0.9966739,0.0001236653,0.00008881803,0.002807604],"study_design_scores_gemma":[0.00001902822,0.0001686513,0.0006867289,0.000002946636,0.000007977983,0.0003030065,0.000004193706,0.0007195986,0.9947457,0.00003839473,0.003299411,0.000004471361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316359,0.006701802,0.05144248,0.0009518439,0.00007986429,0.0002784955,0.0005602303,0.0003751672,0.007974283],"genre_scores_gemma":[0.9787708,0.002070062,0.01421312,0.0002105272,0.00002445401,0.0001055483,0.0004171365,0.00005878784,0.004129561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005729052,"threshold_uncertainty_score":0.002190351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019627419083471,"score_gpt":0.2490883503242818,"score_spread":0.2388920761334471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}