{"id":"W4388776339","doi":"10.1016/j.omtn.2023.102080","title":"Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; University of Massachusetts Medical School; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Aldeyra Therapeutics; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Centre québécois sur les matériaux fonctionnels","keywords":"Conjugate; Oligonucleotide; Drug delivery; In vivo; Small interfering RNA; Nucleic acid; Chemistry; Amphiphile; Gene silencing; Drug carrier; Albumin; Gene delivery; Serum albumin; Pharmacology; Biophysics; Biochemistry; Biology; RNA; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002146423,0.0002741894,0.0002434581,0.0001911982,0.0000908896,0.00005175605,0.000280192,0.0002416289,0.00004475418],"category_scores_gemma":[0.00006055049,0.0002766834,0.0001057769,0.0004239986,0.0001306104,0.000009231804,0.0001382825,0.0001698843,0.00007063166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003025507,"about_ca_system_score_gemma":0.00005357335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003907875,"about_ca_topic_score_gemma":0.00004806789,"domain_scores_codex":[0.998387,0.0001215627,0.0002467512,0.0005950042,0.000177515,0.0004721341],"domain_scores_gemma":[0.9993727,0.00002047958,0.00005830668,0.0003793231,0.00005877246,0.0001103741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522129,0.00009474393,0.003109184,0.00001086466,0.0000846043,0.00007190542,0.0001847321,0.00004956297,0.9921287,0.00003820494,0.0009797729,0.00309553],"study_design_scores_gemma":[0.001573629,0.0006751557,0.009177581,0.00004095498,0.000009985766,0.00002798662,0.00009638682,0.0001688906,0.9845021,0.0001835406,0.003174273,0.0003695527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997972,0.0007895511,0.00015724,0.0002419104,0.0001151585,0.0003065644,0.00001907615,0.00004997813,0.0003485343],"genre_scores_gemma":[0.9973325,0.001188317,0.00006180459,0.0007183047,0.00008114192,0.00004162969,0.00005004457,0.0000535139,0.0004727867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007626618,"threshold_uncertainty_score":0.9999685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019627419083471,"score_gpt":0.2490883503242818,"score_spread":0.2388920761334471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}