{"id":"W4388783411","doi":"10.1002/trc2.12434","title":"Operationalizing selection criteria for clinical trials in Alzheimer's disease: Biomarker and clinical considerations","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"","keywords":"Clinical trial; Medicine; Operationalization; Disease; Biomarker; Protocol (science); Medical physics; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.7617995,0.003443575,0.01086509,0.01049083,0.003502919,0.01935402,0.008097226,0.01096725,0.003231335],"category_scores_gemma":[0.8326774,0.00201289,0.006192737,0.01084109,0.01124403,0.01350141,0.007643833,0.01469397,0.001170081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009326366,"about_ca_system_score_gemma":0.02131905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002075209,"about_ca_topic_score_gemma":0.002747451,"domain_scores_codex":[0.1266569,0.7543828,0.08259592,0.005485685,0.02912411,0.001754582],"domain_scores_gemma":[0.1146097,0.7705827,0.03864144,0.02856475,0.04398182,0.003619539],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01016528,0.0008921476,0.03042854,0.03190789,0.007157872,0.0006946019,0.01227805,0.01053369,0.001892286,0.310591,0.06251161,0.520947],"study_design_scores_gemma":[0.01232721,0.005571367,0.02585009,0.06434906,0.003979336,0.001625516,0.003048317,0.04690056,0.003049189,0.6553875,0.1768334,0.001078424],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02072136,0.09191222,0.572849,0.1592629,0.01710689,0.1112457,0.001790585,0.001020731,0.02409055],"genre_scores_gemma":[0.1588741,0.007545211,0.6857113,0.03360131,0.00547461,0.1061842,0.0009591636,0.0003338205,0.001316348],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.7617995,"threshold_uncertainty_score":0.2937437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7367744824160494,"score_gpt":0.6643475192851973,"score_spread":0.07242696313085206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}