{"id":"W4388789618","doi":"10.1016/j.ymthe.2023.11.007","title":"Myelodysplasia and transgene inactivation in X-CGD-γ retroviral gene therapy: The usual suspects and new players","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Chronic granulomatous disease; Genetic enhancement; Insertional mutagenesis; Biology; Transgene; NADPH oxidase; Severe combined immunodeficiency; Haematopoiesis; Mutagenesis; Gene; Immunology; Stem cell; Virology; Genetics; Mutation; Mutant; Reactive oxygen species","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001271497,0.0003650387,0.000363227,0.0004470285,0.0002472682,0.0009728447,0.0003944621,0.001136563,0.001211124],"category_scores_gemma":[0.0006705038,0.0001988072,0.0002006323,0.000225651,0.002128015,0.001332667,0.0004744823,0.001335947,0.0001469434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781862,"about_ca_system_score_gemma":0.0004450832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002044244,"about_ca_topic_score_gemma":0.00042524,"domain_scores_codex":[0.9997148,0.0001141076,0.0000318654,0.00002718536,0.00007544558,0.00003660658],"domain_scores_gemma":[0.9996815,0.0001873741,0.00006455775,0.00003310006,0.00001115957,0.00002222731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003510056,0.001154033,0.01188893,0.001459079,0.0001385274,0.01838952,0.001090555,0.001750703,0.4354796,0.2904271,0.006504308,0.2282075],"study_design_scores_gemma":[0.001033225,0.01142625,0.02194397,0.001589047,0.0005517278,0.1302752,0.001806913,0.008290867,0.3935086,0.1746544,0.2547326,0.0001872904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5741029,0.3371619,0.03352157,0.01933327,0.001495848,0.00019002,0.0001416729,0.0002866028,0.03376611],"genre_scores_gemma":[0.9043927,0.07874041,0.006275765,0.002247094,0.001161564,0.0001002378,0.00007277803,0.00003483862,0.006974688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271497,"threshold_uncertainty_score":0.006724417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822070855573989,"score_gpt":0.2472796691535789,"score_spread":0.219058960597839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}