{"id":"W4388794664","doi":"10.1093/neuonc/noad179.1202","title":"LTBK-06. IMPACT OF VORASIDENIB TREATMENT ON MUTANT <i>IDH1</i> OR <i>IDH2</i> DIFFUSE GLIOMA TUMOR GROWTH RATE: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PHASE 3 INDIGO STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Medicine; Magnetic resonance imaging; Glioma; Isocitrate dehydrogenase; Nuclear medicine; IDH1; IDH2; Randomized controlled trial; Internal medicine; Urology; Radiology; Pathology; Nuclear magnetic resonance; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001177458,0.0006112066,0.00155303,0.0002442137,0.0001831286,0.0009092149,0.0005628985,0.0008058632,0.007271089],"category_scores_gemma":[0.0008264297,0.0002679308,0.0009913836,0.0002599467,0.0006311715,0.0005796203,0.0001690616,0.001683757,0.001743856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005048102,"about_ca_system_score_gemma":0.0008809725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000537943,"about_ca_topic_score_gemma":0.001593392,"domain_scores_codex":[0.9995803,0.0002286099,0.00002672382,0.00005529004,0.00004505847,0.00006408407],"domain_scores_gemma":[0.9996009,0.00009599462,0.0001074204,0.00003118496,0.00002422427,0.0001403268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8758858,0.00936246,0.002190253,0.001198775,0.0009792359,0.00006823863,0.0000538916,0.0009966824,0.02018495,0.0003026317,0.003898602,0.08487851],"study_design_scores_gemma":[0.6445822,0.3206385,0.01940626,0.000170428,0.001350974,0.0002585247,0.00008576556,0.001456671,0.006753198,0.0004244932,0.004819621,0.00005344562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782236,0.01094747,0.0004371852,0.000832161,0.0003619598,0.0006716928,0.003121975,0.0002924917,0.005111356],"genre_scores_gemma":[0.9901896,0.002880403,0.0005650133,0.0006116732,0.0001280772,0.0005371384,0.002337557,0.00003203381,0.002718435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007271089,"threshold_uncertainty_score":0.02432418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05801742463777383,"score_gpt":0.3693872397532679,"score_spread":0.3113698151154941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}