{"id":"W4388794664","doi":"10.1093/neuonc/noad179.1202","title":"LTBK-06. IMPACT OF VORASIDENIB TREATMENT ON MUTANT <i>IDH1</i> OR <i>IDH2</i> DIFFUSE GLIOMA TUMOR GROWTH RATE: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PHASE 3 INDIGO STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Medicine; Magnetic resonance imaging; Glioma; Isocitrate dehydrogenase; Nuclear medicine; IDH1; IDH2; Randomized controlled trial; Internal medicine; Urology; Radiology; Pathology; Nuclear magnetic resonance; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009705696,0.0007712429,0.002468503,0.0004929499,0.0002531027,0.0000637551,0.0003847009,0.0002221438,0.0001225518],"category_scores_gemma":[0.00142172,0.0003803506,0.0008756494,0.001410608,0.000329964,0.00009813539,0.0001670417,0.0004205972,0.0003365963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006951905,"about_ca_system_score_gemma":0.0008707488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003044275,"about_ca_topic_score_gemma":0.0006973184,"domain_scores_codex":[0.9944525,0.001464023,0.001509302,0.00111408,0.0006506959,0.0008094294],"domain_scores_gemma":[0.987222,0.01000216,0.0008168195,0.001281823,0.0002379682,0.0004392507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7917454,0.02803424,0.004369829,0.0000138601,0.00241674,0.02077818,0.003512981,0.000053311,0.1394187,0.0000370423,0.007638015,0.001981664],"study_design_scores_gemma":[0.8518507,0.03051522,0.00361042,0.0000684694,0.002333547,0.0002708196,0.0008187401,0.0001017074,0.1085037,0.00006911462,0.001568129,0.0002894757],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851285,0.0001304825,0.000001058639,0.004583248,0.0006324498,0.007946505,0.0008724636,0.0002200665,0.0004852127],"genre_scores_gemma":[0.995926,0.0003628659,0.00001583738,0.0009538889,0.000443228,0.001682528,0.0004632988,0.0001082258,0.00004411601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0601053,"threshold_uncertainty_score":0.9998648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05801742463777383,"score_gpt":0.3693872397532679,"score_spread":0.3113698151154941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}