{"id":"W4388798842","doi":"10.1101/2023.11.17.567601","title":"Monocyte subpopulations exhibit distinct TNF-dependent aging signatures","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Monocyte; Tumor necrosis factor alpha; Inflammation; Biology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527844,0.0001286284,0.0001789297,0.0002547262,0.0001005419,0.0002326788,0.00006050641,0.0001366633,0.0009662124],"category_scores_gemma":[0.0001047276,0.00008394119,0.0001150062,0.0001683867,0.0001332878,0.00007640287,0.0001518751,0.0002965723,0.0003341648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149069,"about_ca_system_score_gemma":0.00008650353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003080856,"about_ca_topic_score_gemma":0.0003656032,"domain_scores_codex":[0.999889,0.00001571767,0.000009391881,0.0000302274,0.00002574209,0.00002986189],"domain_scores_gemma":[0.9998859,0.00001325484,0.00003511516,0.0000168086,0.00002403606,0.00002474249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000236349,0.00000868029,0.002433313,0.00001879375,0.000003081819,0.0000358207,0.0000242736,0.00001665552,0.9955816,0.00004457928,0.00004980469,0.00154706],"study_design_scores_gemma":[0.00001954042,0.0003777095,0.2152324,0.00001595883,0.00003449156,0.0006810452,0.0001362197,0.0007373046,0.7789091,0.0002707474,0.003573332,0.00001223261],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939988,0.00171737,0.00251337,0.00007118728,0.00002608407,0.00001114162,0.0009814021,0.00006216608,0.0006185324],"genre_scores_gemma":[0.9949448,0.0005261851,0.001506114,0.00009551732,0.00001969773,0.00001957866,0.0008467762,0.0000161688,0.00202523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009662124,"threshold_uncertainty_score":0.00323236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238171152378066,"score_gpt":0.2436660341952699,"score_spread":0.2212843226714893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}