{"id":"W4388799076","doi":"10.1016/j.gastha.2023.11.004","title":"Body Surface Area-Based Dosing of Infliximab is Superior to Standard Weight-Based Dosing in Children With Very Early Onset Inflammatory Bowel Disease","year":2023,"lang":"en","type":"article","venue":"Gastro Hep Advances","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Institute for Clinical Evaluative Sciences; SickKids Foundation","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Canada Research Chairs; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Dosing; Infliximab; Medicine; Inflammatory bowel disease; Body surface area; Body weight; Internal medicine; Gastroenterology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001788244,0.0002084965,0.0004741552,0.0003646943,0.0001736168,0.0007268394,0.0002280951,0.0003764634,0.0006226876],"category_scores_gemma":[0.00781288,0.0001554179,0.0005203831,0.0004481906,0.0003104722,0.0005135809,0.0003119653,0.0004964811,0.00008455877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004077701,"about_ca_system_score_gemma":0.0003402689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009878202,"about_ca_topic_score_gemma":0.001658863,"domain_scores_codex":[0.9986461,0.0004918916,0.0001734626,0.0002076056,0.0003184192,0.0001625445],"domain_scores_gemma":[0.9933469,0.002096422,0.003647299,0.0001640594,0.0002400963,0.0005051693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001145958,0.00005808259,0.9889346,0.00002922933,0.00008805769,0.00007295088,0.0000479337,0.000217072,0.0005449207,0.00002774629,0.00008131122,0.008752037],"study_design_scores_gemma":[0.0000660317,0.001773545,0.9959145,0.00002258803,0.00009796834,0.0005653291,0.00009434182,0.0007410249,0.0004311343,0.00003611554,0.000251734,0.000005637564],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985228,0.0009643832,0.0001653911,0.00007084429,0.000005445567,0.000004896388,0.00004797008,0.000003633873,0.0002146461],"genre_scores_gemma":[0.999549,0.0001749898,0.0001560732,0.0000261029,0.000008049339,0.000002626961,0.00005819351,0.000001331904,0.0000236198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788244,"threshold_uncertainty_score":0.009457231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00428568936421044,"score_gpt":0.2260416491287479,"score_spread":0.2217559597645375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}