{"id":"W4388805686","doi":"10.1016/j.csbj.2023.11.031","title":"A promising antibiotic candidate, brevinin-1 analogue 5R, against drug-resistant bacteria, with insights into its membrane-targeting mechanism","year":2023,"lang":"en","type":"article","venue":"Computational and Structural Biotechnology Journal","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Antimicrobial; Antimicrobial peptides; Streptococcus pyogenes; Biofilm; Chemistry; Antibiotics; Microbiology; Bacteria; Peptide; Biochemistry; Biology; Staphylococcus aureus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010717,0.0002775759,0.0002409103,0.0001518079,0.000107702,0.0002095328,0.0001960392,0.0003528484,0.0007775257],"category_scores_gemma":[0.000091261,0.00007128456,0.0001915299,0.0001165236,0.0001866968,0.0003032017,0.0001831221,0.0005416625,0.0002588738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158002,"about_ca_system_score_gemma":0.0001218204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142933,"about_ca_topic_score_gemma":0.0002243212,"domain_scores_codex":[0.9999449,0.00001249502,0.000003735895,0.00001402588,0.00001184107,0.00001306754],"domain_scores_gemma":[0.9999655,0.000005973665,0.00001196169,0.00000273007,0.000005314639,0.000008462256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008377779,0.00003679759,0.0001802152,0.0001620164,0.000006724378,0.0001503671,0.00001822045,0.0004523665,0.989536,0.0004058824,0.00008953866,0.008878072],"study_design_scores_gemma":[0.00005813367,0.001705237,0.001786902,0.00004015355,0.00003494204,0.001106452,0.00006449506,0.00216124,0.9720187,0.0003024771,0.0206968,0.00002431286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456828,0.03248282,0.01477447,0.0008765494,0.0001349596,0.00009695539,0.0002961051,0.0001257288,0.005529763],"genre_scores_gemma":[0.9817816,0.007183973,0.008218791,0.000306167,0.00002146858,0.00003416565,0.0002214024,0.00001244792,0.002220068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007775257,"threshold_uncertainty_score":0.002601027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006410467631981061,"score_gpt":0.2085200191834489,"score_spread":0.2021095515514678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}