{"id":"W4388822200","doi":"10.1016/j.rpth.2023.102265","title":"Inhibitor development according to concentrate in severe hemophilia: reporting on 1392 Previously Untreated Patients from Europe and Canada","year":2023,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canadian Hemophilia Society; McMaster University Medical Centre; Izaak Walton Killam Health Centre; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Ontario Clinical Oncology Group","funders":"Grifols; Octapharma; Takeda Pharmaceutical Company; Novo Nordisk; Sanofi; Swedish Orphan Biovitrum; BioMarin Pharmaceutical; CSL Behring; Roche; Bayer; Pfizer","keywords":"Medicine; Haemophilia; Clotting factor; Odds ratio; Internal medicine; Factor IX; Confidence interval; Adverse effect; Haemophilia A; Pediatrics; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008986832,0.0004015302,0.0005483851,0.001798851,0.001288804,0.001261573,0.001012598,0.000451029,0.001367591],"category_scores_gemma":[0.00243955,0.0003697317,0.0006202059,0.004812558,0.0007189487,0.0002768457,0.0008319613,0.0005638131,0.0002314855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01086386,"about_ca_system_score_gemma":0.01730146,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.9479674,"about_ca_topic_score_gemma":0.9352092,"domain_scores_codex":[0.9977937,0.0001464955,0.0002766649,0.000327867,0.00105588,0.0003994209],"domain_scores_gemma":[0.9951575,0.0003697509,0.001588126,0.0001791148,0.001800232,0.0009052326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007327238,0.00001965948,0.9945497,0.00004878894,0.00008229338,0.0002007831,0.0002060674,0.00007643962,0.0001738745,0.00004123565,0.0009851991,0.003542643],"study_design_scores_gemma":[0.00001346146,0.00003636743,0.9974276,0.00003375633,0.00003999712,0.0003880423,0.0003437223,0.0001521226,0.0001488344,0.000009135828,0.00139489,0.00001207569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861286,0.002123181,0.0001501159,0.0001492061,0.00001277947,0.00008408075,0.008453357,0.00002090007,0.002877877],"genre_scores_gemma":[0.9918247,0.00194151,0.0002036208,0.0002162168,0.00001211743,0.00003155282,0.005115166,0.00001133931,0.0006439268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9479674,"threshold_uncertainty_score":0.104678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1716504484285463,"score_gpt":0.4221404742008411,"score_spread":0.2504900257722948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}