{"id":"W4388824157","doi":"10.1038/s41588-023-01563-z","title":"Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Mental Health; National Center for PTSD, U.S. Department of Veterans Affairs; National Institutes of Health; Foundation for the National Institutes of Health; Novo Nordisk Fonden; Lundbeckfonden; Aarhus Universitet; European Commission; National Institute on Alcohol Abuse and Alcoholism; One Mind; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Alliance for Research on Schizophrenia and Depression; Novo Nordisk; VISN 4 Mental Illness Research, Education, and Clinical Center; Office of Research and Development; NIH Clinical Center; H. Lundbeck A/S; U.S. Department of Veterans Affairs; Brain and Behavior Research Foundation","keywords":"Biology; Genome-wide association study; Disease; Cannabis; Genetics; Genetic association; Genome; Public health; Association (psychology); Computational biology; Evolutionary biology; Genotype; Single-nucleotide polymorphism; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001139045,0.0003298639,0.0003917828,0.001195748,0.000645517,0.0007078585,0.0003327232,0.000472979,0.002929721],"category_scores_gemma":[0.002108225,0.000200884,0.0009206938,0.001292747,0.0003081958,0.0002453059,0.0008351523,0.0006134456,0.0001982167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001895932,"about_ca_system_score_gemma":0.0002953286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005209613,"about_ca_topic_score_gemma":0.01088231,"domain_scores_codex":[0.9993269,0.0003140351,0.0000451229,0.0001677504,0.000072567,0.00007354532],"domain_scores_gemma":[0.9988808,0.0004747824,0.0002273237,0.0002498317,0.0000699209,0.00009735172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005532887,0.00008175115,0.9646413,0.00006617192,0.002094307,0.0004298839,0.0001966738,0.0006306206,0.01737139,0.0005695426,0.0003282585,0.01303677],"study_design_scores_gemma":[0.00002700278,0.00009159654,0.9927827,0.00002585275,0.000887132,0.0004279985,0.0001579692,0.001611233,0.002183761,0.0007928914,0.001001508,0.00001031058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938962,0.001416491,0.002745378,0.0002937406,0.00002490051,0.00001103928,0.0005818144,0.00003514443,0.0009954114],"genre_scores_gemma":[0.9982817,0.0002402278,0.001071395,0.00003793287,0.00001329488,0.000003703018,0.0001447518,0.000006794221,0.0002001366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005209613,"threshold_uncertainty_score":0.01035863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158225714365922,"score_gpt":0.3693643964802251,"score_spread":0.3277821393365659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}