{"id":"W4388824157","doi":"10.1038/s41588-023-01563-z","title":"Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Mental Health; National Center for PTSD, U.S. Department of Veterans Affairs; National Institutes of Health; Foundation for the National Institutes of Health; Novo Nordisk Fonden; Lundbeckfonden; Aarhus Universitet; European Commission; National Institute on Alcohol Abuse and Alcoholism; One Mind; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Alliance for Research on Schizophrenia and Depression; Novo Nordisk; VISN 4 Mental Illness Research, Education, and Clinical Center; Office of Research and Development; NIH Clinical Center; H. Lundbeck A/S; U.S. Department of Veterans Affairs; Brain and Behavior Research Foundation","keywords":"Biology; Genome-wide association study; Disease; Cannabis; Genetics; Genetic association; Genome; Public health; Association (psychology); Computational biology; Evolutionary biology; Genotype; Single-nucleotide polymorphism; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324885,0.0001362912,0.0002790234,0.000281049,0.0001591912,0.00003576096,0.0001243636,0.0002624184,0.00001300223],"category_scores_gemma":[0.001280528,0.000118793,0.00005274175,0.0008573743,0.00006805862,0.0000461749,0.0001465393,0.0005332585,0.000003278438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994193,"about_ca_system_score_gemma":0.0006039228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004156295,"about_ca_topic_score_gemma":0.001619634,"domain_scores_codex":[0.998532,0.0001201779,0.0003110088,0.0003559566,0.0002922672,0.0003885645],"domain_scores_gemma":[0.9985556,0.00004626114,0.0001145699,0.0004268394,0.0004595681,0.0003971875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002013028,0.0004786405,0.9792845,0.00009501628,0.00007348098,0.000002821836,0.001448731,0.00001475909,0.0004124612,0.0000158599,0.01478969,0.003363933],"study_design_scores_gemma":[0.0008948913,0.0003479538,0.886575,0.000006963696,0.00003022765,5.221783e-7,0.0005392539,0.0001216999,0.00001225847,0.00003842983,0.1113442,0.00008861566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9289011,0.00477451,0.0000624141,0.06514181,0.0001197612,0.0008499819,0.00009203888,0.00004634598,0.00001206616],"genre_scores_gemma":[0.9943506,0.001945444,0.0001996492,0.001272508,0.0001118156,0.0001228502,0.000216612,0.00002590044,0.001754612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09655452,"threshold_uncertainty_score":0.484424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158225714365922,"score_gpt":0.3693643964802251,"score_spread":0.3277821393365659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}