{"id":"W4388824359","doi":"10.21203/rs.3.rs-3576281/v1","title":"Chimerization of the Anti-Viral CD8+ T Cell Response with A Broad Anti-Tumor T Cell Response Reverses Inhibition of Checkpoint Blockade Therapy by Oncolytic Virotherapy","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Hyundai Hope On Wheels; National Institutes of Health; University of Minnesota; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Blockade; Virotherapy; CD8; Viral therapy; T cell; Cytotoxic T cell; Immunotherapy; Medicine; Virology; Cancer research; Immunology; Biology; Coronavirus disease 2019 (COVID-19); Virus; Immune system; Receptor; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935316,0.0004281515,0.000300629,0.0002188196,0.0001444068,0.0004498627,0.000297643,0.0005644121,0.003392449],"category_scores_gemma":[0.0001854915,0.0002115394,0.0002834804,0.0001160959,0.0002739564,0.0002083677,0.0003379309,0.001894019,0.0007222515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004509504,"about_ca_system_score_gemma":0.0003256164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004556187,"about_ca_topic_score_gemma":0.0004116179,"domain_scores_codex":[0.9997582,0.00003829751,0.00001318995,0.00005856985,0.00004758381,0.00008417064],"domain_scores_gemma":[0.9998801,0.00002895704,0.00002301547,0.00002014351,0.000007722278,0.00004002135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003335561,0.00008515343,0.00009518187,0.00002356672,0.00001166996,0.0000348461,0.00001366392,0.0007277658,0.9959122,0.0007998151,0.0001828778,0.001779709],"study_design_scores_gemma":[0.0001116415,0.0003896699,0.0006635969,0.000004765326,0.00001973294,0.0001832132,0.00001538882,0.003692864,0.9896722,0.000175132,0.005065852,0.000006048505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870697,0.0005025973,0.007325725,0.0003090993,0.00007566263,0.00007649423,0.0005464683,0.0003655152,0.003728709],"genre_scores_gemma":[0.9941676,0.0001172846,0.002380851,0.00009463739,0.00001118886,0.00004032667,0.0002338595,0.00006391876,0.002890385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003392449,"threshold_uncertainty_score":0.0113489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760545539524867,"score_gpt":0.3637150472437093,"score_spread":0.3161095918484606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}