{"id":"W4388824359","doi":"10.21203/rs.3.rs-3576281/v1","title":"Chimerization of the Anti-Viral CD8+ T Cell Response with A Broad Anti-Tumor T Cell Response Reverses Inhibition of Checkpoint Blockade Therapy by Oncolytic Virotherapy","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Hyundai Hope On Wheels; National Institutes of Health; University of Minnesota; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Blockade; Virotherapy; CD8; Viral therapy; T cell; Cytotoxic T cell; Immunotherapy; Medicine; Virology; Cancer research; Immunology; Biology; Coronavirus disease 2019 (COVID-19); Virus; Immune system; Receptor; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00930225,0.0007039407,0.00143897,0.0015458,0.0003207328,0.0001134953,0.0009019333,0.0006235499,0.0009028672],"category_scores_gemma":[0.001051489,0.0005092662,0.0006590743,0.002575841,0.00141735,0.0001278197,0.0008101649,0.003104758,0.0000520765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008035277,"about_ca_system_score_gemma":0.004039138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008788457,"about_ca_topic_score_gemma":0.00002400791,"domain_scores_codex":[0.9856144,0.006159065,0.001265739,0.001334201,0.004418341,0.001208277],"domain_scores_gemma":[0.9924941,0.002011955,0.0007767489,0.002738427,0.001608007,0.0003707609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08330371,0.001558571,0.003557544,0.001967601,0.0002033112,0.0001399847,0.001959355,0.0002608015,0.9046434,0.000002642334,0.001768675,0.0006343774],"study_design_scores_gemma":[0.007051224,0.005386622,0.03769021,0.003212055,0.00005852564,0.00002695499,0.0009786222,0.0004075482,0.9409008,0.00008619563,0.003758623,0.0004426267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865218,0.001421455,0.00007744988,0.003487068,0.0001585282,0.007248602,0.0006568237,0.0001353228,0.0002929688],"genre_scores_gemma":[0.9796094,0.003794128,0.0001951876,0.00008438155,0.0002002435,0.0004730138,0.0002186985,0.0003366887,0.01508822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07625249,"threshold_uncertainty_score":0.9997359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760545539524867,"score_gpt":0.3637150472437093,"score_spread":0.3161095918484606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}