{"id":"W4388824756","doi":"10.1167/tvst.12.11.24","title":"Safety and Efficacy of Adeno-Associated Viral Gene Therapy in Patients With Retinal Degeneration: A Systematic Review and Meta-Analysis","year":2023,"lang":"en","type":"review","venue":"Translational Vision Science & Technology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"University of Ottawa","keywords":"Medicine; Choroideremia; Adverse effect; Meta-analysis; Visual acuity; Genetic enhancement; Relative risk; Randomized controlled trial; Internal medicine; Ophthalmology; Confidence interval; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009119527,0.0002575431,0.001878844,0.000811234,0.0001003189,0.0000197337,0.0002900466,0.0002284577,0.00001138548],"category_scores_gemma":[0.000156656,0.0001665557,0.0002369248,0.002760956,0.0004569539,0.00001241589,0.00006092704,0.000116847,0.00000125129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001505858,"about_ca_system_score_gemma":0.0001887937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002370821,"about_ca_topic_score_gemma":0.00001660396,"domain_scores_codex":[0.9979041,0.0001288958,0.0007961711,0.0005785058,0.0004059155,0.0001864651],"domain_scores_gemma":[0.9989924,0.00005169964,0.0004298478,0.0002785802,0.0002077557,0.00003972339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001384598,0.002677633,0.01727752,0.6426616,0.1920866,0.00002797077,0.0005682371,0.0003746838,0.0009707365,0.005981057,0.0001149242,0.1358745],"study_design_scores_gemma":[0.01215875,0.00695315,0.03735887,0.0542282,0.8658341,0.00006631293,0.00007899394,0.0001846784,0.0004911357,0.0008947529,0.01622544,0.005525675],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002533707,0.9956108,0.0002130673,0.0001774247,0.000006859894,0.00138043,0.00005021316,0.00001343497,0.00001400295],"genre_scores_gemma":[0.008937846,0.9901085,0.0004187166,0.00003927302,0.000002238181,0.00008512096,0.0003458374,0.00001516589,0.00004732761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6737474,"threshold_uncertainty_score":0.6791945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062890889761963,"score_gpt":0.3291823239412037,"score_spread":0.2985534150435841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}