{"id":"W4388824756","doi":"10.1167/tvst.12.11.24","title":"Safety and Efficacy of Adeno-Associated Viral Gene Therapy in Patients With Retinal Degeneration: A Systematic Review and Meta-Analysis","year":2023,"lang":"en","type":"review","venue":"Translational Vision Science & Technology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"University of Ottawa","keywords":"Medicine; Choroideremia; Adverse effect; Meta-analysis; Visual acuity; Genetic enhancement; Relative risk; Randomized controlled trial; Internal medicine; Ophthalmology; Confidence interval; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01104373,0.002221881,0.01747237,0.007079183,0.0005973086,0.003394892,0.002111003,0.0021068,0.004755811],"category_scores_gemma":[0.03358949,0.001302207,0.02693942,0.008619495,0.0007908579,0.001824186,0.00125719,0.001440052,0.0003456268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002628111,"about_ca_system_score_gemma":0.004747135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006255643,"about_ca_topic_score_gemma":0.01359121,"domain_scores_codex":[0.9902853,0.003967748,0.003501338,0.0009228612,0.001063879,0.0002588878],"domain_scores_gemma":[0.9752105,0.01803383,0.004247743,0.0005592919,0.001713727,0.0002349532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0008211082,0.00001897476,0.002049514,0.7653492,0.2179796,0.00008250322,0.00007704659,0.0002516267,0.0001455557,0.0001172,0.0006206199,0.01248691],"study_design_scores_gemma":[0.0005583692,0.0002711191,0.004452323,0.1229722,0.8673276,0.000167592,0.00008154488,0.0001510619,0.0001486761,0.0002466113,0.003588185,0.00003468997],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002133461,0.996563,0.0002323431,0.0001431273,0.00008614101,0.0002100921,0.0004126876,0.0000124542,0.0002066583],"genre_scores_gemma":[0.07073819,0.9254508,0.00105311,0.0008260472,0.0001925915,0.0009050081,0.0005964116,0.00002000679,0.0002179122],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01747237,"threshold_uncertainty_score":0.05840552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062890889761963,"score_gpt":0.3291823239412037,"score_spread":0.2985534150435841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}