{"id":"W4388825176","doi":"10.1103/physrevlett.131.218401","title":"AlphaFold2 Can Predict Single-Mutation Effects","year":2023,"lang":"en","type":"article","venue":"Physical Review Letters","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Institute for Basic Science","keywords":"Mutation; Phenotype; Deformation (meteorology); Range (aeronautics); Materials science; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002668827,0.001379644,0.0009552081,0.001124815,0.0004279522,0.0007290394,0.000605464,0.0007503994,0.0016799],"category_scores_gemma":[0.005770775,0.0003961471,0.000811676,0.0005507449,0.0002770706,0.001450503,0.0006434289,0.0008679834,0.0007099782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004833178,"about_ca_system_score_gemma":0.0003994221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345568,"about_ca_topic_score_gemma":0.001435834,"domain_scores_codex":[0.9994702,0.0001478398,0.00003910973,0.0001532521,0.000145301,0.00004427514],"domain_scores_gemma":[0.9965385,0.001859315,0.0004462279,0.0005473424,0.0004332908,0.0001754412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001945693,0.0002805269,0.2855042,0.0006626338,0.0007118884,0.0005285144,0.0002709098,0.4351903,0.1316067,0.005051825,0.01017547,0.1280713],"study_design_scores_gemma":[0.00003515611,0.0001656534,0.02831572,0.00002802061,0.00005574939,0.0002427906,0.0000264813,0.9327556,0.03047996,0.005000855,0.002839034,0.00005497566],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7967397,0.001361102,0.1838141,0.0004534115,0.0001533445,0.00004758429,0.004480857,0.009867889,0.003081881],"genre_scores_gemma":[0.9541219,0.000214995,0.04097907,0.00009983064,0.00003071575,0.0000574858,0.003404282,0.0005872267,0.0005046073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002668827,"threshold_uncertainty_score":0.01411426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006830674052677104,"score_gpt":0.2624275390009564,"score_spread":0.2555968649482793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}