{"id":"W4388833028","doi":"10.3390/cells12222655","title":"Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Laurentian University; NOSM University","funders":"Natural Sciences and Engineering Research Council of Canada; Northern Ontario Heritage Fund Corporation; Northern Ontario Academic Medicine Association","keywords":"Anidulafungin; Echinocandin; Biology; Echinocandins; Caspofungin; Microbiology; Micafungin; Fluconazole; Candida glabrata; Posaconazole; Efflux; Itraconazole; Drug resistance; Amphotericin B; Genetics; Candida albicans; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006282686,0.0005308504,0.002349978,0.000256425,0.00006288367,0.00003666133,0.0002396094,0.0004704984,0.0001415314],"category_scores_gemma":[0.0002543686,0.0003982911,0.0004940862,0.001158703,0.000125619,0.00003986545,0.00006573473,0.0007269264,0.0002234199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005204754,"about_ca_system_score_gemma":0.0008277768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001489229,"about_ca_topic_score_gemma":0.001317638,"domain_scores_codex":[0.9970241,0.0002317172,0.0007280055,0.0008033044,0.0006062767,0.0006065856],"domain_scores_gemma":[0.9983771,0.0002428822,0.000330732,0.0007646829,0.000113175,0.0001714111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00273777,0.006624339,0.003588518,0.5760965,0.01169179,0.1350964,0.002024645,0.00001606531,0.02476323,0.01891008,0.04581015,0.1726405],"study_design_scores_gemma":[0.002448348,0.0004919058,0.003429208,0.1568026,0.004023076,0.000027433,0.0002294407,0.000005289492,0.001204181,0.0008154321,0.8284537,0.002069348],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00126375,0.9922897,0.00009831341,0.00001853189,0.0001929845,0.001364647,0.0002338079,0.0001309473,0.004407369],"genre_scores_gemma":[0.001467064,0.9720519,0.0001734205,0.00005756003,0.0000542627,0.00006876914,0.0003327637,0.0001404784,0.02565378],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7826436,"threshold_uncertainty_score":0.9998469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378568454129632,"score_gpt":0.3018772277489252,"score_spread":0.2580915432076288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}