{"id":"W4388833028","doi":"10.3390/cells12222655","title":"Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Laurentian University; NOSM University","funders":"Natural Sciences and Engineering Research Council of Canada; Northern Ontario Heritage Fund Corporation; Northern Ontario Academic Medicine Association","keywords":"Anidulafungin; Echinocandin; Biology; Echinocandins; Caspofungin; Microbiology; Micafungin; Fluconazole; Candida glabrata; Posaconazole; Efflux; Itraconazole; Drug resistance; Amphotericin B; Genetics; Candida albicans; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180206,0.0006777595,0.0003728406,0.001643776,0.0002634555,0.0009916254,0.0004206336,0.0007467257,0.001298142],"category_scores_gemma":[0.0002273809,0.0001782603,0.0005178953,0.0008523113,0.0002447981,0.0004307866,0.0003520464,0.0004790563,0.0004210157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000544016,"about_ca_system_score_gemma":0.0003118567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007162911,"about_ca_topic_score_gemma":0.0004799235,"domain_scores_codex":[0.999806,0.00002867662,0.00002888318,0.00003445233,0.00006402528,0.00003804049],"domain_scores_gemma":[0.9998832,0.00001739313,0.00004604102,0.000005665862,0.00003500473,0.00001270801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007557475,0.0001451219,0.008835685,0.008589608,0.0002993819,0.007521011,0.0003814017,0.001092996,0.7369124,0.00753495,0.005818009,0.2221137],"study_design_scores_gemma":[0.0001405202,0.001385108,0.1478869,0.002890149,0.001521974,0.0365588,0.0009602071,0.003070864,0.4775601,0.007361078,0.3204969,0.0001675207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1327433,0.84753,0.00530694,0.001387184,0.0003616322,0.0001573045,0.001064453,0.0003012152,0.01114803],"genre_scores_gemma":[0.3954219,0.5868275,0.005297318,0.0008036296,0.0004707329,0.0001466056,0.002289786,0.00003158847,0.008711075],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001643776,"threshold_uncertainty_score":0.004342675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378568454129632,"score_gpt":0.3018772277489252,"score_spread":0.2580915432076288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}