{"id":"W4388833895","doi":"10.1097/01.cot.0000996492.23995.f2","title":"Technique Highlights How Abnormal RNA Splicing Leads to Disease","year":2023,"lang":"en","type":"article","venue":"Oncology Times","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RNA splicing; Disease; RNA; Computational biology; Alternative splicing; Biology; Medicine; Genetics; Gene; Gene isoform; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003091842,0.0001418644,0.0001637757,0.0001390544,0.0001457785,0.0000283125,0.0002674821,0.0001621001,0.00005053373],"category_scores_gemma":[0.0001602081,0.0001262968,0.0000799886,0.0002385809,0.00007219348,0.000005478462,0.000263587,0.0001209354,0.0003011417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003967466,"about_ca_system_score_gemma":0.0001920727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001733586,"about_ca_topic_score_gemma":0.00003203644,"domain_scores_codex":[0.9987952,0.00008418792,0.0001189018,0.0003641836,0.0001403397,0.0004971664],"domain_scores_gemma":[0.9991965,0.00002988146,0.00003505138,0.0003423546,0.00006275438,0.000333429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270004,0.00002933395,0.001274137,0.00001356141,0.0000202409,0.000117488,0.00001706573,0.00004690167,0.8949578,0.0002963298,0.1000611,0.003039098],"study_design_scores_gemma":[0.0004290128,0.0008721959,0.007562228,0.00002438228,0.00001576422,0.00002050488,0.00004836298,0.0001741032,0.5762413,0.0001065098,0.4142165,0.0002891349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772134,0.000134605,0.001203413,0.01131297,0.0001328419,0.0004295178,0.00001583625,0.0001026761,0.009454736],"genre_scores_gemma":[0.9125794,0.0001398827,0.0009883775,0.0006506436,0.0003614659,0.0002066617,0.00009766766,0.00002936854,0.08494649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3187165,"threshold_uncertainty_score":0.5150232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130585127111369,"score_gpt":0.300920043362334,"score_spread":0.2878615306511971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}