{"id":"W4388834338","doi":"10.1038/s41596-023-00901-z","title":"Co-fractionation–mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain","year":2023,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of New Brunswick; University of Regina","funders":"Canadian Institutes of Health Research; Government of Canada; ALS Society of Canada","keywords":"Proteome; Proteomics; Fractionation; Computational biology; Mass spectrometry; Biology; Human brain; Chemistry; Biochemistry; Neuroscience; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002470201,0.0001908783,0.0001913115,0.0003435015,0.00009059282,0.00006264431,0.0001591339,0.0004773269,0.00006672108],"category_scores_gemma":[0.001190529,0.0001885442,0.00004902468,0.0006670092,0.00004180755,0.0000138176,0.00005848879,0.0004733293,0.00006438079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002639571,"about_ca_system_score_gemma":0.00009065436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006588964,"about_ca_topic_score_gemma":0.00005907134,"domain_scores_codex":[0.9985304,0.0002006931,0.0002360727,0.0005360848,0.0002045102,0.0002922596],"domain_scores_gemma":[0.9993856,0.00004999212,0.00008870109,0.0002505974,0.0001147345,0.0001103798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004606259,0.00003592953,0.0009643471,0.0000262234,0.000010928,0.00002137978,0.00005318235,0.00000329042,0.9775329,0.0004821116,0.0199282,0.0004808591],"study_design_scores_gemma":[0.001565114,0.0007576441,0.03615431,0.00004262352,0.000003183587,0.00002298525,0.00005209322,0.00001207643,0.4505284,0.0003299625,0.5102286,0.0003030084],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8520145,0.00004310002,0.00300853,0.01659483,0.001363167,0.1205961,0.0003299153,0.0002084854,0.005841356],"genre_scores_gemma":[0.4896075,0.00002380805,0.0202952,0.01271005,0.007387334,0.4210881,0.002460748,0.0002767028,0.04615048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5270045,"threshold_uncertainty_score":0.7688612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751289610268276,"score_gpt":0.319840062386802,"score_spread":0.3023271662841192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}