{"id":"W4388834513","doi":"10.1021/acs.molpharmaceut.3c00780","title":"Adjuvant Auger Electron-Emitting Radioimmunotherapy with [<sup>111</sup>In]In-DOTA-Panitumumab in a Mouse Model of Local Recurrence and Metastatic Progression of Human Triple-Negative Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Panitumumab; Radioimmunotherapy; DOTA; Medicine; Cancer research; Oncology; Nuclear medicine; Cancer; Internal medicine; Colorectal cancer; Monoclonal antibody; KRAS; Immunology; Antibody; In vivo; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123155,0.0004769171,0.0005359831,0.0002363676,0.0001041425,0.0002256688,0.0003088049,0.0004275144,0.000760054],"category_scores_gemma":[0.00006340043,0.0002400926,0.0003263676,0.0001414273,0.0002779273,0.0002016803,0.0001097314,0.0007889347,0.0002021971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770725,"about_ca_system_score_gemma":0.0002300174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145116,"about_ca_topic_score_gemma":0.001894562,"domain_scores_codex":[0.9998579,0.0000326535,0.000007704327,0.00002800315,0.00002720492,0.00004655494],"domain_scores_gemma":[0.9999251,0.0000097044,0.00002499347,0.00001262365,0.000005552334,0.0000219135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00100494,0.0004133562,0.0001518569,0.00004454472,0.0000127373,0.00003865697,0.00001718558,0.0002779838,0.9961208,0.00008054914,0.00007431313,0.001763159],"study_design_scores_gemma":[0.0002171141,0.01013002,0.003126232,0.000006535357,0.00006530494,0.0003026246,0.0000174174,0.001352955,0.9829658,0.0000358465,0.00177193,0.000008251923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964658,0.001090109,0.001068894,0.00007303144,0.00003615411,0.00007992316,0.0001556072,0.00008063931,0.0009499282],"genre_scores_gemma":[0.9932638,0.0009731524,0.002051891,0.00004419576,0.00001437563,0.0001034528,0.0002630385,0.00002216296,0.003263844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145116,"threshold_uncertainty_score":0.002542615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0377303845779337,"score_gpt":0.3844641905614742,"score_spread":0.3467338059835405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}