{"id":"W4388835858","doi":"10.1097/pr9.0000000000001113","title":"Effects of pharmacogenetic profiles on pediatric pain relief and adverse events with ibuprofen and oxycodone","year":2023,"lang":"en","type":"article","venue":"PAIN Reports","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; University of British Columbia; University of Calgary; Université de Montréal; University of Alberta; University of Saskatchewan; Women and Children’s Health Research Institute","funders":"Canadian Institutes of Health Research; Stollery Children’s Hospital Foundation; Children's Hospital Foundation; University of Alberta; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oxycodone; Ibuprofen; Medicine; Adverse effect; Anesthesia; CYP2D6; CYP2C9; Internal medicine; Opioid; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008101916,0.0002336688,0.0002817213,0.0003255568,0.000152734,0.0003574128,0.0001908428,0.0002298805,0.001624769],"category_scores_gemma":[0.002731458,0.0001220502,0.0004178966,0.000543255,0.0001997916,0.0002055393,0.0002176619,0.0002711034,0.0001431065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001939792,"about_ca_system_score_gemma":0.0001856558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574998,"about_ca_topic_score_gemma":0.001393378,"domain_scores_codex":[0.9990224,0.0003091993,0.0001102056,0.0002087143,0.0002390896,0.0001104529],"domain_scores_gemma":[0.9979737,0.0004512964,0.001227726,0.00007801871,0.0001308522,0.0001383555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002495137,0.00002683216,0.9971651,0.000009923528,0.00007741785,0.00009768797,0.00004611316,0.00003210468,0.0004061195,0.00001456498,0.00004118314,0.001833372],"study_design_scores_gemma":[0.00000674502,0.0001575816,0.9991142,0.000003789286,0.00002510916,0.0003469255,0.00004426545,0.00009635271,0.0001070554,0.000007219578,0.00008950638,0.000001256344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993073,0.0002110354,0.00009674668,0.00001722956,0.000002200499,0.000007859342,0.0001925796,0.000001379138,0.0001636742],"genre_scores_gemma":[0.9995572,0.00006797489,0.000116109,0.00001211705,0.000003696441,0.000008284544,0.0001705589,0.000001526585,0.00006260051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001624769,"threshold_uncertainty_score":0.005435348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006985428457617572,"score_gpt":0.2447137922338443,"score_spread":0.2377283637762267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}