{"id":"W4388835858","doi":"10.1097/pr9.0000000000001113","title":"Effects of pharmacogenetic profiles on pediatric pain relief and adverse events with ibuprofen and oxycodone","year":2023,"lang":"en","type":"article","venue":"PAIN Reports","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; University of British Columbia; University of Calgary; Université de Montréal; University of Alberta; University of Saskatchewan; Women and Children’s Health Research Institute","funders":"Canadian Institutes of Health Research; Stollery Children’s Hospital Foundation; Children's Hospital Foundation; University of Alberta; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oxycodone; Ibuprofen; Medicine; Adverse effect; Anesthesia; CYP2D6; CYP2C9; Internal medicine; Opioid; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002500531,0.0001534642,0.0002593175,0.0002171231,0.00004897725,0.000003173311,0.00002818347,0.00004777314,0.000009666484],"category_scores_gemma":[0.0006307352,0.00011763,0.00003275214,0.0003357914,0.000039088,0.00002875105,0.00005245542,0.00009422691,0.000004520887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001310797,"about_ca_system_score_gemma":0.00003213874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001062575,"about_ca_topic_score_gemma":7.388724e-7,"domain_scores_codex":[0.9986466,0.0002489159,0.0002578157,0.0003216754,0.0003067942,0.0002181568],"domain_scores_gemma":[0.998977,0.0004748692,0.0001758724,0.0002155935,0.0000355265,0.00012113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001371008,0.0001133078,0.9818321,0.002325449,0.00007720295,0.001363738,0.0001903386,0.000005978678,0.00265221,0.000004120349,0.005525203,0.005773262],"study_design_scores_gemma":[0.001086669,0.0007589007,0.9927309,0.0003472196,0.0003240168,0.000009312807,0.00009106127,0.0006040664,0.002415118,0.0001032112,0.001364518,0.0001649948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975362,0.0006426011,0.00008390409,0.0002333322,0.00007696683,0.001150419,0.000001190597,0.00009901919,0.0001763911],"genre_scores_gemma":[0.9963718,0.001275995,0.0003421214,0.0003324775,0.000114401,0.00009214831,0.00002826531,0.00002818948,0.001414595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089882,"threshold_uncertainty_score":0.4796813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006985428457617572,"score_gpt":0.2447137922338443,"score_spread":0.2377283637762267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}