{"id":"W4388845105","doi":"10.1093/brain/awad397","title":"Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Montreal Neurological Institute and Hospital; Consortium canadien en neurodégénérescence associée au vieillissement; Weston Brain Institute; Alzheimer's Disease Neuroimaging Initiative; Fondation Brain Canada; McGill University; Alzheimer's Association","keywords":"Tangle; Phosphorylation; Neuroscience; Modulation (music); Amyloid (mycology); Psychology; Biology; Cell biology; Internal medicine; Chemistry; Endocrinology; Medicine; Pathology; Philosophy; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003947876,0.000289993,0.0002376625,0.0004524219,0.0003229487,0.0003595283,0.0002404447,0.000175903,0.002993937],"category_scores_gemma":[0.001382667,0.0001375145,0.0002237191,0.0002406128,0.0002792349,0.0001760807,0.0002174318,0.0002064042,0.0003350156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958518,"about_ca_system_score_gemma":0.0002478304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006009677,"about_ca_topic_score_gemma":0.006928988,"domain_scores_codex":[0.9998196,0.00002677425,0.00001091615,0.00007808247,0.00003788316,0.00002677681],"domain_scores_gemma":[0.999551,0.00006670221,0.0002416963,0.0000474718,0.00004852272,0.00004462354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004223809,0.00003524585,0.9872943,0.00002425785,0.00006682717,0.0003086932,0.0003811216,0.00003232916,0.00500563,0.0001116646,0.0002323382,0.006085246],"study_design_scores_gemma":[0.000004475686,0.00007826416,0.9982885,0.00000462031,0.00001893027,0.0007577087,0.0001470314,0.00005135362,0.0003091387,0.00006551175,0.0002713432,0.000003174702],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984391,0.0003465361,0.0001290054,0.00004300773,0.000008430634,0.000006610172,0.00036326,0.000004352173,0.0006596673],"genre_scores_gemma":[0.9991234,0.0001224558,0.00009802788,0.00002342196,0.000008221969,0.000005531462,0.0001735329,0.000003248103,0.0004422322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006009677,"threshold_uncertainty_score":0.01194936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109008212251201,"score_gpt":0.3627394807129096,"score_spread":0.2537312684617086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}