{"id":"W4388845105","doi":"10.1093/brain/awad397","title":"Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Montreal Neurological Institute and Hospital; Consortium canadien en neurodégénérescence associée au vieillissement; Weston Brain Institute; Alzheimer's Disease Neuroimaging Initiative; Fondation Brain Canada; McGill University; Alzheimer's Association","keywords":"Tangle; Phosphorylation; Neuroscience; Modulation (music); Amyloid (mycology); Psychology; Biology; Cell biology; Internal medicine; Chemistry; Endocrinology; Medicine; Pathology; Philosophy; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727217,0.00009654756,0.0001597652,0.0002796267,0.00003757932,0.00001177675,0.00003328941,0.00006047954,0.00009426933],"category_scores_gemma":[0.00005971245,0.00008598428,0.00005226297,0.000426352,0.00003706764,0.0001015609,0.00001787579,0.00006607072,0.0001933164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000094872,"about_ca_system_score_gemma":0.00004643986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003770732,"about_ca_topic_score_gemma":0.00003024816,"domain_scores_codex":[0.9990247,0.00005843156,0.0001969502,0.0001957202,0.0003403591,0.0001838027],"domain_scores_gemma":[0.999483,0.00015986,0.00005273899,0.0001878882,0.00004449555,0.0000720313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001660374,0.001104999,0.8742251,0.0002021594,0.00102137,0.0001551964,0.002133729,0.00599938,0.01390718,0.002703207,0.005197895,0.09168939],"study_design_scores_gemma":[0.001597798,0.0001996887,0.9846609,0.00008905336,0.00001537461,0.000001169075,0.0003244793,0.007855638,0.003803311,0.001150298,0.0002300463,0.0000722817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968151,0.0003200202,0.00009060347,0.001280758,0.00003349322,0.0004471943,0.00001670385,0.00005826734,0.0009378624],"genre_scores_gemma":[0.9987701,0.00004948243,0.00007578967,0.00004985272,0.0000460291,0.00002739024,0.0004018023,0.00001775981,0.0005617631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1104357,"threshold_uncertainty_score":0.3506337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109008212251201,"score_gpt":0.3627394807129096,"score_spread":0.2537312684617086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}