{"id":"W4388850779","doi":"10.1021/acsnano.3c06526","title":"Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Scripps Research Institute","keywords":"Adjuvant; Germinal center; TLR9; Vaccination; Influenza vaccine; Virology; Antigen; Biology; Influenza A virus subtype H5N1; Antibody; Immunology; Virus; Gene; B cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063491,0.0002257334,0.0001362577,0.00007590903,0.00005959675,0.000137766,0.0001286388,0.0003203997,0.0002440254],"category_scores_gemma":[0.00005787265,0.00009044083,0.0001535063,0.00004879129,0.00007957324,0.0001750721,0.0001135736,0.0002006836,0.0001060155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129327,"about_ca_system_score_gemma":0.00008117042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002587583,"about_ca_topic_score_gemma":0.0005081781,"domain_scores_codex":[0.9999454,0.000009853061,0.000003747336,0.0000125176,0.00001712422,0.00001140038],"domain_scores_gemma":[0.9999707,0.000004346785,0.000007627573,0.000002066182,0.000007784225,0.000007560287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001677866,0.000009598211,0.00003822989,0.00001696474,0.000002388899,0.00001338159,0.000002671503,0.0001642772,0.999233,0.00001575704,0.00001139153,0.0004755168],"study_design_scores_gemma":[0.00001032188,0.0006314918,0.0009948243,0.000003226031,0.00001287471,0.0001152898,0.0000125323,0.005199613,0.9920311,0.00002073153,0.0009636027,0.000004460349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99261,0.001109447,0.005399282,0.00004407125,0.00002409706,0.00002990576,0.00005148178,0.00004262965,0.0006889677],"genre_scores_gemma":[0.9926707,0.0004197533,0.005898808,0.00003637077,0.000005934115,0.00001886737,0.00007832146,0.000005414633,0.000865906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003203997,"threshold_uncertainty_score":0.0009383559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06140554031975574,"score_gpt":0.356842181966682,"score_spread":0.2954366416469263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}