{"id":"W4388850779","doi":"10.1021/acsnano.3c06526","title":"Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Scripps Research Institute","keywords":"Adjuvant; Germinal center; TLR9; Vaccination; Influenza vaccine; Virology; Antigen; Biology; Influenza A virus subtype H5N1; Antibody; Immunology; Virus; Gene; B cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00107357,0.0004296463,0.0008163241,0.0005684039,0.0003436185,0.00006233114,0.0003189744,0.0001877371,0.00004463728],"category_scores_gemma":[0.001251631,0.0003641234,0.0002224245,0.001400052,0.00008992585,0.000243077,0.0004250038,0.0003762539,0.0004808258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675212,"about_ca_system_score_gemma":0.0002309092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495,"about_ca_topic_score_gemma":0.00001827842,"domain_scores_codex":[0.9959052,0.000195804,0.0009915626,0.0006347625,0.001174873,0.00109786],"domain_scores_gemma":[0.9979762,0.0002291176,0.0003198695,0.0007939438,0.00041236,0.0002685506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001132991,0.0006933432,0.004339564,0.0008863037,0.000353422,0.0003812913,0.001520097,0.00005087442,0.9885756,0.0003204095,0.0001137777,0.001632324],"study_design_scores_gemma":[0.005269815,0.0008232518,0.004756183,0.0009867034,0.000128146,0.0000291965,0.0006481114,0.0009304684,0.9802083,0.0001343481,0.005722329,0.0003631891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928311,0.002031636,0.00002562085,0.0006342862,0.00005831761,0.003662684,0.00001977768,0.0005862363,0.0001503634],"genre_scores_gemma":[0.9944105,0.0000516761,0.003636052,0.00008678451,0.000124811,0.0006844917,0.00001120129,0.0001020653,0.0008924376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008367345,"threshold_uncertainty_score":0.9998811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06140554031975574,"score_gpt":0.356842181966682,"score_spread":0.2954366416469263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}