{"id":"W4388851283","doi":"10.1002/alz.13508","title":"Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; H. Lundbeck A/S; Rush University; F. Hoffmann-La Roche; National Human Genome Research Institute; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; National Institute on Aging; Alzheimer's Association","keywords":"Genetic architecture; Genome-wide association study; Endophenotype; Heritability; Episodic memory; Biology; Cognitive decline; Candidate gene; Effects of sleep deprivation on cognitive performance; Cognition; Psychology; Genetics; Disease; Gene; Quantitative trait locus; Dementia; Neuroscience; Medicine; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379019,0.0003405858,0.0003177199,0.0006957979,0.0003312407,0.0006118766,0.0004178309,0.0003295895,0.001642209],"category_scores_gemma":[0.002828121,0.0001423037,0.0004523797,0.0009370079,0.0003185874,0.0002846585,0.0005679343,0.000478443,0.000165972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909773,"about_ca_system_score_gemma":0.0002824393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002770701,"about_ca_topic_score_gemma":0.003655188,"domain_scores_codex":[0.9995767,0.0001258777,0.00004157694,0.0001562199,0.00005144158,0.00004814985],"domain_scores_gemma":[0.9980015,0.0004104667,0.0009139333,0.0003032755,0.0002146584,0.0001561478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002105956,0.00002340423,0.9932787,0.00002451658,0.0002807524,0.0000706922,0.00006503936,0.0001410267,0.001310348,0.00008240106,0.0001911374,0.004321406],"study_design_scores_gemma":[0.000008086368,0.00006011471,0.9985387,0.000009794777,0.0001234567,0.000158706,0.00002563012,0.0002260197,0.0003124592,0.0002509143,0.0002813276,0.000004814076],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996333,0.0006440798,0.0008621687,0.0001296213,0.00001215412,0.000008938298,0.001464264,0.00002644071,0.0005193947],"genre_scores_gemma":[0.9983853,0.0001349503,0.0004329291,0.00004797678,0.00001777828,0.00001305521,0.0007654084,0.00000497336,0.0001976857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002770701,"threshold_uncertainty_score":0.007292986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05514913944320197,"score_gpt":0.3131048172114437,"score_spread":0.2579556777682417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}