{"id":"W4388851331","doi":"10.1002/acr2.11619","title":"Effect of Romosozumab Treatment in Postmenopausal Women With Osteoporosis and Knee Osteoarthritis: Results From a Substudy of a Phase 3 Clinical Trial","year":2023,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"UCB Pharma; Chugai Pharmaceutical; Alexion Pharmaceuticals; Amgen","keywords":"Medicine; Osteoarthritis; WOMAC; Placebo; Internal medicine; Osteoporosis; Physical therapy; Knee pain; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009881957,0.0003156943,0.001998728,0.0002140248,0.00004561374,0.00001748961,0.0001585423,0.0002274698,0.00006128552],"category_scores_gemma":[0.000331548,0.0002287545,0.00007353323,0.0003718075,0.0002192813,0.0001180736,0.000179219,0.0001399312,0.0000253366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007342255,"about_ca_system_score_gemma":0.0002204406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517345,"about_ca_topic_score_gemma":0.001045637,"domain_scores_codex":[0.9969495,0.0005458044,0.001203163,0.0006407497,0.0002163225,0.000444481],"domain_scores_gemma":[0.9973468,0.001451842,0.0004033049,0.0005431087,0.00005761933,0.00019735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6666411,0.003201084,0.03265606,0.00008187076,0.0005244314,0.00112829,0.009331527,3.469479e-7,0.002175243,0.00005295327,0.00003562987,0.2841715],"study_design_scores_gemma":[0.6008118,0.3860416,0.003562294,0.0004199923,0.0002524002,0.0001593209,0.002413491,0.000007445585,0.006018655,0.00007043003,0.00007323299,0.0001693564],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994138,0.0003421931,1.971299e-7,0.0001344814,0.0002191911,0.00456772,0.0003354347,0.00004374554,0.0002190542],"genre_scores_gemma":[0.9980957,0.0002950836,0.0002068474,0.00001553084,0.0000145054,0.0008172256,0.0003853418,0.00003728534,0.0001324684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3828405,"threshold_uncertainty_score":0.9328338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868690503667698,"score_gpt":0.3567434532845832,"score_spread":0.3280565482479062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}